Sycheva L P, Zhurkov V S
Tsitol Genet. 1989 Mar-Apr;23(2):45-9.
A regressive modification index (RMI = beta M - beta/beta.100) is suggested to quantitatively evaluate modification of the mutagenic effect in experiments on mammals. It is based on the correlation of regressive equation "dose mutagen--effects" coefficients beta M and beta in variants with and without modifier, respectively. Regressive modification indices of various doses of phenobarbital are calculated in experiments on rats with cyclophosphamide and fotrin.
建议采用回归修饰指数（RMI = βM - β/β.100）来定量评估哺乳动物实验中诱变效应的修饰情况。它基于“剂量-诱变剂-效应”回归方程系数βM和β的相关性，分别对应有修饰剂和无修饰剂的变体。在使用环磷酰胺和福替嘧啶对大鼠进行的实验中，计算了不同剂量苯巴比妥的回归修饰指数。
