Zhurkov V S, Sycheva L P
Vestn Ross Akad Med Nauk. 1993(1):41-6.
The paper summarizes the results of several studies to modify the effects of the indirect-acting mutagen cyclophosphamide and the direct-acting fotrin in the presence of varying activity of the microsomal monooxygenase system. It also first shows how the effects of the mutagens are modified by inducing or inhibiting monooxygenase activity. A regression modification index is proposed to measure the level and direction of modification of mutagenic effects in experiments on mammals.
本文总结了几项研究的结果，这些研究旨在改变间接作用诱变剂环磷酰胺和直接作用诱变剂福替瑞林在微粒体单加氧酶系统活性不同时的作用效果。本文还首次展示了如何通过诱导或抑制单加氧酶活性来改变诱变剂的作用效果。文中提出了一个回归修正指数，用于衡量在哺乳动物实验中诱变效应的修正水平和方向。
