澳大利亚成年人维生素D水平季节性变化的模式及影响因素研究：季节性D队列研究
Investigating the patterns and determinants of seasonal variation in vitamin D status in Australian adults: the Seasonal D Cohort Study.
作者信息
King Laura, Dear Keith, Harrison Simone L, van der Mei Ingrid, Brodie Alison M, Kimlin Michael G, Lucas Robyn M
机构信息
National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia.
Duke Kunshan University, Kunshan, China.
出版信息
BMC Public Health. 2016 Aug 26;16(1):892. doi: 10.1186/s12889-016-3582-z.
BACKGROUND
Vitamin D status generally varies seasonally with changing solar UVB radiation, time in the sun, amount of skin exposed, and, possibly, diet. The Seasonal D Study was designed to quantify the amplitude and phase of seasonal variation in the serum concentration of 25-hydroxyvitamin D, (25OH)D)) and identify the determinants of the amplitude and phase and those of inter-individual variability in seasonal pattern.
METHODS
The Seasonal D Study collected data 2-monthly for 12 months, including demographics, personal sun exposure using a diary and polysulphone dosimeters over 7 days, and blood for serum 25(OH)D concentration. The study recruited 333 adults aged 18-79 years living in Canberra (35°S, n = 168) and Brisbane (27°South, n = 165), Australia.
DISCUSSION
We report the study design and cohort description for the Seasonal D Study. The study has collected a wealth of data to examine inter- and intra-individual seasonal variation in vitamin D status and serum 25(OH)D levels in Australian adults.
背景
维生素D状态通常随季节变化，这与太阳紫外线B辐射、日照时间、暴露皮肤面积以及可能的饮食有关。季节性D研究旨在量化血清25-羟基维生素D（25OH）D）浓度季节性变化的幅度和相位，并确定幅度和相位的决定因素以及季节性模式个体间差异的决定因素。
方法
季节性D研究为期12个月，每2个月收集一次数据，包括人口统计学信息、使用日记和聚砜剂量计记录的7天个人日照情况，以及用于检测血清25（OH）D浓度的血液样本。该研究招募了333名年龄在18 - 79岁之间、居住在澳大利亚堪培拉（南纬35°，n = 168）和布里斯班（南纬27°，n = 165）的成年人。
讨论
我们报告了季节性D研究的研究设计和队列描述。该研究收集了大量数据，以研究澳大利亚成年人维生素D状态和血清25（OH）D水平的个体间和个体内季节性变化。
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