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起源于残留息肉的结直肠癌：恶性转化模型

Colorectal Cancer with Residual Polyp of Origin: A Model of Malignant Transformation.

作者信息

Druliner Brooke R, Rashtak Shahrooz, Ruan Xiaoyang, Bae Taejeong, Vasmatzis Nikolaos, O'Brien Daniel, Johnson Ruth, Felmlee-Devine Donna, Washechek-Aletto Jill, Basu Nivedita, Liu Hongfang, Smyrk Thomas, Abyzov Alexej, Boardman Lisa A

机构信息

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905.

Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, 55905.

出版信息

Transl Oncol. 2016 Aug;9(4):280-6. doi: 10.1016/j.tranon.2016.06.002. Epub 2016 Jul 9.

DOI:10.1016/j.tranon.2016.06.002
PMID:27567950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4941582/
Abstract

The majority of colorectal cancers (CRCs) arise from adenomatous polyps. In this study, we sought to present the underrecognized CRC with the residual polyp of origin (CRC RPO+) as an entity to be utilized as a model to study colorectal carcinogenesis. We identified all subjects with biopsy-proven CRC RPO+ that were evaluated over 10 years at Mayo Clinic, Rochester, MN, and compared their clinical and pathologic characteristics to CRC without remnant polyps (CRC RPO-). Overall survival and disease-free survival overlap with an equivalent hazard ratio between CRC RPO+ and RPO- cases when age, stage, and grade are adjusted. The somatic genomic profile obtained by whole genome sequencing and the gene expression profiles by RNA-seq for CRC RPO+ tumors were compared with that of age -and gender-matched CRC RPO- evaluated by The Cancer Genome Atlas. CRC RPO+ cases were more commonly found with lower-grade, earlier-stage disease than CRC RPO-. However, within the same disease stage and grade, their clinical course is very similar to that of CRC RPO-. The mutation frequencies of commonly mutated genes in CRC are similar between CRC RPO+ and RPO- cases. Likewise, gene expression patterns are indistinguishable between the RPO+ and RPO- cases. We have confirmed that CRC RPO+ is clinically and biologically similar to CRC RPO- and may be utilized as a model of the adenoma to carcinoma transition.

摘要

大多数结直肠癌（CRC）起源于腺瘤性息肉。在本研究中，我们试图将起源息肉残留的未被充分认识的结直肠癌（CRC RPO+）作为一个实体呈现出来，用作研究结直肠癌发生机制的模型。我们识别出在明尼苏达州罗切斯特市梅奥诊所接受评估超过10年且经活检证实为CRC RPO+的所有受试者，并将他们的临床和病理特征与无残留息肉的结直肠癌（CRC RPO-）进行比较。当对年龄、分期和分级进行调整后，CRC RPO+和RPO-病例的总生存率和无病生存率重叠，风险比相当。将通过全基因组测序获得的CRC RPO+肿瘤的体细胞基因组图谱以及通过RNA测序获得的基因表达图谱，与经癌症基因组图谱评估的年龄和性别匹配的CRC RPO-的图谱进行比较。与CRC RPO-相比，CRC RPO+病例更常表现为低级别、早期疾病。然而，在相同的疾病分期和分级内，它们的临床病程与CRC RPO-非常相似。CRC RPO+和RPO-病例中结直肠癌常见突变基因的突变频率相似。同样，RPO+和RPO-病例之间的基因表达模式也难以区分。我们已经证实，CRC RPO+在临床和生物学上与CRC RPO-相似，可作为腺瘤向癌转变过程的模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/2a3f6a50fe03/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/37fb41bf0f1b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/61de5ca47d6d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/2a3f6a50fe03/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/37fb41bf0f1b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/61de5ca47d6d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80cb/4941582/2a3f6a50fe03/gr3.jpg

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