丝氨酸/苏氨酸激酶和多胺在延伸因子1A非经典功能调控中的作用
Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A.
作者信息
Migliaccio Nunzia, Martucci Nicola M, Ruggiero Immacolata, Sanges Carmen, Ohkubo Shinji, Lamberti Annalisa, Agostinelli Enzo, Arcari Paolo
机构信息
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 8031, Naples, Italy.
ERT, Research Technology GmbH, Sieboldstrasse 3, 97230, Estenfeld, Germany.
出版信息
Amino Acids. 2016 Oct;48(10):2339-52. doi: 10.1007/s00726-016-2311-3. Epub 2016 Aug 27.
The link between eukaryotic translation elongation factor 1A (eEF1A) and signal transduction pathways through the regulatory mechanism of phosphorylation has never been considered. In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and apoptosis. In this context, polyamines seem to play a role in the regulation of the translation elongation process by modulating the Ser/Thr kinases involved in the phosphorylation of translation elongation factors.
真核生物翻译延伸因子1A（eEF1A）与通过磷酸化调节机制的信号转导途径之间的联系从未被考虑过。在本综述中，我们重点关注识别eEF1A1和eEF1A2亚型的丝氨酸（Ser）和苏氨酸（Thr）残基并调节它们参与细胞存活和凋亡等不同细胞过程的各种激酶。在这种情况下，多胺似乎通过调节参与翻译延伸因子磷酸化的Ser/Thr激酶，在翻译延伸过程的调节中发挥作用。
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