Liccini Anthony, Malmstrom Theodore K
Department of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO.
Department of Psychiatry, Saint Louis University School of Medicine, St. Louis, MO.
J Am Med Dir Assoc. 2016 Sep 1;17(9):846-51. doi: 10.1016/j.jamda.2016.07.007.
Diabetes mellitus is associated with premature aging, and chronic diabetes is associated with significant physical and cognitive complications. We aimed to examine frailty and sarcopenia rates and 6-month health outcomes in a clinic-based sample of patients with diabetes.
This study was an observational study. Participants were recruited from June 2014 to August 2014, and follow-up was conducted 6 months after day of screening.
Participants were recruited at outpatient endocrinology, geriatric, and internal medicine clinics affiliated with Saint Louis University in St. Louis, Missouri.
Participants were persons with diabetes mellitus ages 50 to 90.
Frailty and sarcopenia were identified using the FRAIL and SARC-F screens, respectively. A chart review of the patient's health record was performed on day of screening and at follow-up. A 6-month phone questionnaire was performed to evaluate health outcomes. Logistic regressions were used to evaluate health outcomes.
A total of 198 persons with diabetes were recruited. Of the sample, 32.3% of sample was nonfrail, 38.9% was prefrail, and 28.8% was frail; 29.3% of the sample was identified to have sarcopenia. Prefrail [odds ratio (OR) 2.92, 95% confidence interval (CI) 1.15-7.42; P = .025] and frail (OR 4.70, 95% CI 1.67-13.19; P = .003) participants were more likely to be hospitalized overnight at 6-month follow-up. Frail (OR 3.57 95% CI 1.27-10.04; P = .016) participants were more likely to have a new activities of daily living (ADL) disability at follow-up; this association was not present for prefrail participants (OR 1.30, 95% CI .50-3.37; P = .59). Participants with sarcopenia were more likely to be hospitalized (OR 3.80, 95% CI 1.67-8.61; P = .001) and to have a new ADL disability (OR 4.24, 95% CI 1.76-10.18; P = .001) at 6-month follow-up.
Among clinic patients with diabetes mellitus ages 50-90 year old, frailty and sarcopenia prevalence is high, and both syndromes are predictors of being hospitalized overnight and new ADL disability after 6 months.
糖尿病与早衰相关，慢性糖尿病与严重的身体和认知并发症相关。我们旨在研究以门诊为基础的糖尿病患者样本中的衰弱和肌肉减少症发生率以及6个月的健康结局。
本研究为观察性研究。参与者于2014年6月至2014年8月招募，并在筛查日后6个月进行随访。
参与者在密苏里州圣路易斯市圣路易斯大学附属的门诊内分泌科、老年医学科和内科诊所招募。
参与者为年龄在50至90岁的糖尿病患者。
分别使用FRAIL和SARC-F筛查来识别衰弱和肌肉减少症。在筛查日和随访时对患者的健康记录进行病历审查。通过6个月的电话问卷来评估健康结局。使用逻辑回归来评估健康结局。
共招募了198名糖尿病患者。在样本中，32.3%的样本无衰弱，38.9%为衰弱前期，28.8%为衰弱；29.3%的样本被确定患有肌肉减少症。衰弱前期（比值比[OR] 2.92，95%置信区间[CI] 1.15 - 7.42；P = 0.025）和衰弱（OR 4.70，95% CI 1.67 - 13.19；P = 0.003）的参与者在6个月随访时更有可能过夜住院。衰弱（OR 3.57，95% CI 1.27 - 10.04；P = 0.016）的参与者在随访时更有可能出现新的日常生活活动（ADL）残疾；衰弱前期参与者不存在这种关联（OR 1.30，95% CI 0.50 - 3.37；P = 0.59）。患有肌肉减少症的参与者在6个月随访时更有可能住院（OR 3.80，95% CI 1.67 - 8.61；P = 0.001）并出现新的ADL残疾（OR 4.24，95% CI 1.76 - 10.18；P = 0.001）。
在年龄为50 - 90岁的门诊糖尿病患者中，衰弱和肌肉减少症的患病率很高，并且这两种综合征都是6个月后过夜住院和新的ADL残疾的预测因素。
