Zhang Fan, Han Yan, Mao Yonghua, Zheng Liming, Li Wenjian
Department of Endocrinology, Changzhou Third People's Hospital, Changzhou, 213001, China.
Department of Clinical Nutrition, Changzhou Third People's Hospital, Changzhou, 213001, China.
J Endocrinol Invest. 2025 Jul 8. doi: 10.1007/s40618-025-02649-7.
This study examined the potential correlation between chitinase-3-like protein-1 (CHI3L1) and sarcopenia in patients with type 2 diabetes mellitus (T2DM). The findings aim to establish a preliminary foundation and valuable reference information for future studies in this area.
239 patients with T2DM were enrolled and categorized into groups based on their serum CHI3L1 tertiles. The study compared the incidence of sarcopenia in each group and systematically identified independent risk factors for sarcopenia using multivariate logistic regression analysis. A model was constructed to assess the relative risk of CHI3L1 for sarcopenia in patients with T2DM, and the predictive efficacy of CHI3L1 was analyzed using receiver operating characteristic (ROC) and calibration curves.
The results showed that the prevalence of sarcopenia in patients with T2DM was 13.81%. The study confidently found a significant correlation between higher serum CHI3L1 levels and increased prevalence of sarcopenia in patients with T2DM. Through multivariate logistic regression analysis, CHI3L1 was independently associated with the presence of sarcopenia in patients with T2DM. Additionally, ROC curve analysis demonstrated that CHI3L1 had good predictive efficacy for sarcopenia with an area under the ROC curve of 0.795 [0.707, 0.883].
In patients with T2DM, higher serum levels of CHI3L1 were significantly associated with an increased prevalence of sarcopenia.
本研究探讨2型糖尿病（T2DM）患者中几丁质酶-3样蛋白-1（CHI3L1）与肌肉减少症之间的潜在相关性。研究结果旨在为该领域的未来研究奠定初步基础并提供有价值的参考信息。
纳入239例T2DM患者，并根据其血清CHI3L1三分位数进行分组。本研究比较了每组肌肉减少症的发生率，并使用多因素逻辑回归分析系统地确定了肌肉减少症的独立危险因素。构建一个模型来评估CHI3L1对T2DM患者肌肉减少症的相对风险，并使用受试者工作特征（ROC）曲线和校准曲线分析CHI3L1的预测效能。
结果显示，T2DM患者中肌肉减少症的患病率为13.81%。本研究确切发现，T2DM患者血清CHI3L1水平升高与肌肉减少症患病率增加之间存在显著相关性。通过多因素逻辑回归分析，CHI3L1与T2DM患者肌肉减少症的存在独立相关。此外，ROC曲线分析表明，CHI3L1对肌肉减少症具有良好的预测效能，ROC曲线下面积为0.795[0.707,0.883]。
在T2DM患者中，血清CHI3L1水平升高与肌肉减少症患病率增加显著相关。
