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Episodic sequence memory is supported by a theta-gamma phase code.

作者信息

Heusser Andrew C, Poeppel David, Ezzyat Youssef, Davachi Lila

机构信息

Department of Psychology, New York University, New York, New York, USA.

Center for Neural Science, New York University, New York, New York, USA.

出版信息

Nat Neurosci. 2016 Oct;19(10):1374-80. doi: 10.1038/nn.4374. Epub 2016 Aug 29.


DOI:10.1038/nn.4374
PMID:27571010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5039104/
Abstract

The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are represented by neural cell assemblies firing at higher frequencies (gamma) and sequential order is encoded by the specific timing of firing with respect to a lower frequency oscillation (theta). During episodic sequence memory formation in humans, we provide evidence that items in different sequence positions exhibit greater gamma power along distinct phases of a theta oscillation. Furthermore, this segregation is related to successful temporal order memory. Our results provide compelling evidence that memory for order, a core component of an episodic memory, capitalizes on the ubiquitous physiological mechanism of theta-gamma phase-amplitude coupling.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/9608219a4da5/nihms808250f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/489b45c01f47/nihms808250f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/664853ca7785/nihms808250f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/9608219a4da5/nihms808250f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/489b45c01f47/nihms808250f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/664853ca7785/nihms808250f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a6c/5039104/9608219a4da5/nihms808250f3.jpg

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[3]
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[4]
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[3]
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[4]
Impaired theta and low-gamma directed information flow in the hippocampal-prefrontal circuit underlies working memory deficits in APP/PS1 mice.

Behav Brain Funct. 2025-7-5

[5]
Frontal midline theta and cross-frequency coupling during short term memory and resting state.

Neuroimage Rep. 2022-8-25

[6]
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[7]
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[9]
Visual Processing by Hierarchical and Dynamic Multiplexing.

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[10]
Two-dimensional neural geometry underpins hierarchical organization of sequence in human working memory.

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本文引用的文献

[1]
The hippocampus: a special place for time.

Ann N Y Acad Sci. 2016-4

[2]
Spatial Sequence Coding Differs during Slow and Fast Gamma Rhythms in the Hippocampus.

Neuron. 2016-1-20

[3]
How the hippocampus preserves order: the role of prediction and context.

Trends Cogn Sci. 2015-2

[4]
Temporal memory is shaped by encoding stability and intervening item reactivation.

J Neurosci. 2014-10-15

[5]
Slow-Theta-to-Gamma Phase-Amplitude Coupling in Human Hippocampus Supports the Formation of New Episodic Memories.

Cereb Cortex. 2016-1

[6]
Untangling cross-frequency coupling in neuroscience.

Curr Opin Neurobiol. 2015-4

[7]
Engineering a memory with LTD and LTP.

Nature. 2014-7-17

[8]
Similarity breeds proximity: pattern similarity within and across contexts is related to later mnemonic judgments of temporal proximity.

Neuron. 2014-3-5

[9]
Hippocampal activity patterns carry information about objects in temporal context.

Neuron. 2014-3-5

[10]
The influence of context boundaries on memory for the sequential order of events.

J Exp Psychol Gen. 2013-8-19

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