Heusser Andrew C, Poeppel David, Ezzyat Youssef, Davachi Lila
Department of Psychology, New York University, New York, New York, USA.
Center for Neural Science, New York University, New York, New York, USA.
Nat Neurosci. 2016 Oct;19(10):1374-80. doi: 10.1038/nn.4374. Epub 2016 Aug 29.
The meaning we derive from our experiences is not a simple static extraction of the elements but is largely based on the order in which those elements occur. Models propose that sequence encoding is supported by interactions between high- and low-frequency oscillations, such that elements within an experience are represented by neural cell assemblies firing at higher frequencies (gamma) and sequential order is encoded by the specific timing of firing with respect to a lower frequency oscillation (theta). During episodic sequence memory formation in humans, we provide evidence that items in different sequence positions exhibit greater gamma power along distinct phases of a theta oscillation. Furthermore, this segregation is related to successful temporal order memory. Our results provide compelling evidence that memory for order, a core component of an episodic memory, capitalizes on the ubiquitous physiological mechanism of theta-gamma phase-amplitude coupling.
我们从自身经历中获得的意义并非对各种元素的简单静态提取，而是在很大程度上基于这些元素出现的顺序。模型表明，序列编码由高频和低频振荡之间的相互作用支持，即经历中的元素由以较高频率（伽马）放电的神经细胞集合体来表征，而序列顺序则由相对于较低频率振荡（西塔）的特定放电时间来编码。在人类情景序列记忆形成过程中，我们提供证据表明，处于不同序列位置的项目在西塔振荡的不同阶段表现出更强的伽马功率。此外，这种分离与成功的时间顺序记忆有关。我们的结果提供了令人信服的证据，表明作为情景记忆核心组成部分的顺序记忆，利用了西塔-伽马相位-振幅耦合这一普遍存在的生理机制。
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