Spangenberg A, Maghsoodi N, Dulnoan D, Moore A E, Edwards S, Frost M L, Hampson G
Department of Clinical Chemistry and Metabolic Medicine, St Thomas' Hospital, 5th Floor, North Wing, London, SE1 7EH, UK.
Osteoporosis Unit, Guy's Hospital, London, SE1 9RT, UK.
Calcif Tissue Int. 2016 Dec;99(6):608-615. doi: 10.1007/s00223-016-0186-7. Epub 2016 Aug 30.
Lean mass (LM) and fat mass (FM) are closely related to bone mass (BM) in post-menopausal women, although their relative importance is unclear. Angiogenic factors which control angiogenesis may influence BM, LM and FM. The aim of the study was to compare the contribution of LM and FM to bone mineral density (BMD) and the association between these tissues and circulating angiogenic factors. The study population comprised of 392 post-menopausal women aged mean [SD] 61.8 [6.4] years. BMD was measured at the lumbar spine (LS), neck of femur and total hip (TH) by dual-energy X-ray absorptiometry (DXA). DXA scan was also used to determine LM and FM. Angiopoietin-1 and 2 (ANG-1, ANG-2) were measured by sandwich enzyme-linked immunosorbent assay. Following adjustment for confounders, significant positive independent associations were seen between LM with BMD at all skeletal sites (TH: p < 0.0001) and FM with BMD at the hip sites (TH: p = 0.004). When BMD and LM were regressed against the angiogenic factors, positive associations were seen between ANG-2 with LM (p = 0.002) and LS BMD (p = 0.05). Negative associations were observed between the ratio of ANG-1/ANG-2 with LS BMD (p = 0.014), TH BMD (p = 0.049) and LM (p = 0.029). FM and fat distribution (android/gynoid fat ratio) were negatively associated with ANG-1 (p = 0.006) and ANG-2 (p = 0.004), respectively. ANG-1 and ANG-2 may be involved in the maintenance of bone, muscle and fat mass.
在绝经后女性中，瘦体重（LM）和脂肪量（FM）与骨量（BM）密切相关，尽管它们的相对重要性尚不清楚。控制血管生成的血管生成因子可能会影响骨量、瘦体重和脂肪量。本研究的目的是比较瘦体重和脂肪量对骨矿物质密度（BMD）的贡献，以及这些组织与循环血管生成因子之间的关联。研究人群包括392名平均年龄为[标准差]61.8[6.4]岁的绝经后女性。采用双能X线吸收法（DXA）测量腰椎（LS）、股骨颈和全髋（TH）的骨密度。DXA扫描还用于测定瘦体重和脂肪量。采用夹心酶联免疫吸附测定法测量血管生成素-1和-2（ANG-1、ANG-2）。在对混杂因素进行校正后，发现瘦体重与所有骨骼部位的骨密度之间存在显著的正独立关联（全髋：p<0.0001），脂肪量与髋部部位的骨密度之间存在显著的正独立关联（全髋：p=0.004）。当骨密度和瘦体重与血管生成因子进行回归分析时，发现ANG-2与瘦体重（p=0.002）和腰椎骨密度（p=0.05）之间存在正相关。观察到ANG-1/ANG-2比值与腰椎骨密度（p=0.014）、全髋骨密度（p=0.049）和瘦体重（p=0.029）之间存在负相关。脂肪量和脂肪分布（腹型/臀型脂肪比值）分别与ANG-1（p=0.006）和ANG-2（p=0.004）呈负相关。ANG-1和ANG-2可能参与骨骼、肌肉和脂肪量的维持。
