Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea.
J Clin Endocrinol Metab. 2014 Oct;99(10):3811-20. doi: 10.1210/jc.2014-1564. Epub 2014 Jun 24.
Fat and muscle are linked to bone metabolism.
The objective of the study was to investigate the association of fat mass (FM) and lean mass (LM) with bone mineral density (BMD) according to gender and age.
This was a population-based, cross-sectional study from Korea National Health and Nutrition Examination Surveys.
15,036 Koreans (6692 men and 8344 women) aged 10-95 years.
BMD and body compositions were measured using dual-energy X-ray absorptiometry. BMD was determined at the femoral neck, total hip, and lumbar spine. Body compositions included total FM (TFM), percentage FM (PFM), truncal FM (TrFM), total LM (TLM), and appendicular skeletal muscle mass/weight (ASM/Wt).
We categorized each man and woman into one of three age groups, based on changes in age-related BMD and the hormonal status. In all gender and age groups, TFM, PFM, and TrFM associated inversely with BMD (P < .001-.034), whereas TLM and ASM/Wt associated positively (P < .001-.037) after adjusting for confounders. The negative contribution of FM (P < .001-.034), and the positive contribution of LM (P < .001-.035) on BMD were significantly stronger in men than in women. The associations were strongest in men of growing age (P = .003-.040). When we subdivided the subjects into four groups based on the median values of PFM and TLM, FM had a greater effect than LM on BMD in men (P < .001-.006).
These results demonstrate that the effects of FM and LM on BMD may be based on gender and age.
脂肪和肌肉与骨骼代谢有关。
本研究旨在根据性别和年龄，调查脂肪量（FM）和瘦体量（LM）与骨密度（BMD）的关系。
这是一项来自韩国国家健康和营养检查调查的基于人群的横断面研究。
15036 名韩国人（6692 名男性和 8344 名女性），年龄在 10-95 岁之间。
使用双能 X 射线吸收法测量 BMD 和身体成分。BMD 测定于股骨颈、全髋和腰椎。身体成分包括总 FM（TFM）、FM 百分比（PFM）、躯干 FM（TrFM）、总 LM（TLM）和四肢骨骼肌质量/重量（ASM/Wt）。
根据与年龄相关的 BMD 和激素状态的变化，我们将每个男性和女性分为三个年龄组之一。在所有性别和年龄组中，TFM、PFM 和 TrFM 与 BMD 呈负相关（P <.001-.034），而 TLM 和 ASM/Wt 与 BMD 呈正相关（P <.001-.037），在调整混杂因素后。FM（P <.001-.034）的负贡献和 LM（P <.001-.035）对 BMD 的正贡献在男性中明显强于女性。在生长年龄的男性中，相关性最强（P =.003-.040）。当我们根据 PFM 和 TLM 的中位数将受试者分为四组时，FM 对 BMD 的影响大于 LM（P <.001-.006）。
这些结果表明，FM 和 LM 对 BMD 的影响可能基于性别和年龄。
