Wong Eric K W, Mahmood Muhammad N, Salopek Thomas G
Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Pediatr Dermatol. 2016 Nov;33(6):e368-e371. doi: 10.1111/pde.12953. Epub 2016 Aug 30.
Congenital melanocytic nevi (CMNs) naturally evolve throughout life, growing proportionately with the child, darkening, and exhibiting textural or surface changes (e.g., papillomatous, verrucous, cerebriform), hypertrichosis, and, later in life, lightening of pigmentation. We report the case of a 5-year-old child with complete resolution of a medium-sized CMN involving the distal left leg and foot via sclerosis and in the absence of any halo phenomenon. Spontaneous regression of CMN via sclerosis is rare, and it is thought that an immunologic mechanism different from the mechanism that the halo phenomenon induces mediates this regression. We reviewed the literature on this phenomenon and discuss how it might lead to regression of the nevus.
先天性黑素细胞痣（CMNs）在一生中会自然演变，与儿童同步生长，颜色变深，并出现质地或表面变化（如乳头状、疣状、脑回状）、多毛症，在生命后期色素沉着会变浅。我们报告了一例5岁儿童的病例，其左下肢远端和足部的中等大小CMN通过硬化完全消退，且未出现任何晕轮现象。CMN通过硬化自发消退的情况很少见，人们认为介导这种消退的免疫机制不同于晕轮现象所诱导的机制。我们回顾了关于这一现象的文献，并讨论了它可能如何导致痣的消退。
