Laboratory of Dynamic Immunobiology, Institute for Immunology, Department of Basic Biomedical Sciences, School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Medical Science Building A107, Tsinghua University, Beijing 100084, China.
Nat Rev Immunol. 2016 Oct;16(10):612-25. doi: 10.1038/nri.2016.94. Epub 2016 Aug 30.
T follicular helper (TFH) cells play a crucial part in the development of humoral immunity by controlling the formation of, and the cellular reactions that occur in, germinal centres. Within these organized lymphoid tissue microstructures, B cells proliferate and somatically mutate to produce long-lived, high-affinity plasma cells and memory B cells. TFH cells exhibit unique molecular, cellular and tissue-dynamic features that are integral to their development and function but that are not necessarily compatible with the classical paradigm of effector CD4(+) T cell differentiation. Here, I discuss recent advances in TFH cell biology and their implications for our understanding of T cell differentiation and memory in humoral immunity from spatiotemporal and functional perspectives.
滤泡辅助性 T（TFH）细胞在控制生发中心的形成和其中发生的细胞反应方面，对体液免疫的发展起着至关重要的作用。在这些组织化的淋巴组织微结构中，B 细胞增殖并体细胞突变，产生长寿命、高亲和力的浆细胞和记忆 B 细胞。TFH 细胞表现出独特的分子、细胞和组织动态特征，这些特征是其发育和功能所必需的，但不一定与经典的效应 CD4(+)T 细胞分化范例兼容。在这里，我从时空和功能的角度讨论 TFH 细胞生物学的最新进展及其对我们理解体液免疫中 T 细胞分化和记忆的意义。
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