Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
Department of Microbiology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Exp Mol Med. 2024 Jun;56(6):1365-1372. doi: 10.1038/s12276-024-01254-7. Epub 2024 Jun 3.
Inside germinal centers (GCs), antigen-specific B cells rely on precise interactions with immune cells and strategic localization between the dark and light zones to clonally expand, undergo affinity maturation, and differentiate into long-lived plasma cells or memory B cells. Follicular helper T (Tfh) cells, the key gatekeepers of GC-dependent humoral immunity, exhibit remarkable dynamic positioning within secondary lymphoid tissues and rely on intercellular interactions with antigen-presenting cells (APCs) during their differentiation and execution of B-cell-facilitating functions within GCs. In this review, we briefly cover the transcriptional regulation of Tfh cell differentiation and function and explore the molecular mechanisms governing Tfh cell motility, their interactions with B cells within GCs, and the impact of their dynamic behavior on humoral responses.
在生发中心（GC）内，抗原特异性 B 细胞依靠与免疫细胞的精确相互作用以及在暗区和亮区之间的战略定位来进行克隆性扩增、亲和力成熟，并分化为长寿浆细胞或记忆 B 细胞。滤泡辅助 T（Tfh）细胞是 GC 依赖性体液免疫的关键守门员，在次级淋巴组织中表现出显著的动态定位，并在分化过程中依赖与抗原呈递细胞（APC）的细胞间相互作用，在 GC 内执行 B 细胞辅助功能。在这篇综述中，我们简要介绍了 Tfh 细胞分化和功能的转录调控，并探讨了控制 Tfh 细胞迁移的分子机制、它们与 GC 内 B 细胞的相互作用，以及它们的动态行为对体液反应的影响。
