使用氧化还原/酸协同催化剂高效对映选择性合成氧杂轮烯。
Efficient Enantioselective Synthesis of Oxahelicenes Using Redox/Acid Cooperative Catalysts.
机构信息
The Institute of Scientific and Industrial Research (ISIR), Osaka University , Mihogaoka, Ibaraki-shi, Osaka 567-0047, Japan.
Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University , Yahaba, Iwate 028-3694, Japan.
出版信息
J Am Chem Soc. 2016 Sep 14;138(36):11481-4. doi: 10.1021/jacs.6b07424. Epub 2016 Sep 6.
An efficient and enantioselective synthesis of oxa[9]helicenes has been established via vanadium(V)-catalyzed oxidative coupling/intramolecular cyclization of polycyclic phenols. A newly developed vanadium complex cooperatively functions as both a redox and Lewis acid catalyst to promote the present sequential reaction and afford oxa[9]helicenes in good yields with up to 94% ee.
通过钒(V)催化多环酚的氧化偶联/分子内环化反应，建立了一种高效对映选择性合成氧杂[9]螺旋化合物的方法。一种新开发的钒配合物协同作为氧化还原和路易斯酸催化剂，促进了这一连续反应，以高达 94%的对映选择性，获得了良好收率的氧杂[9]螺旋化合物。
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