Schober Lukas, Sako Makoto, Takizawa Shinobu, Gröger Harald, Sasai Hiroaki
Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany.
Chem Commun (Camb). 2020 Sep 11;56(70):10151-10154. doi: 10.1039/d0cc02621b. Epub 2020 Jul 31.
An enantioselective oxa-Piancatelli reaction was established for the first time using a chiral vanadium(v) catalyst. The dual Brønsted and Lewis acid properties of the vanadium catalyst afforded 4-hydroxycyclopent-2-enone derivatives in up to 90% yields and with 93 : 7 enantiomeric ratios, as well as >20 : 1 diastereomeric ratios.
首次使用手性钒（V）催化剂建立了对映选择性氧杂-Piancatelli反应。钒催化剂的双重布朗斯特酸和路易斯酸性质可提供产率高达90%、对映体比例为93:7以及非对映体比例>20:1的4-羟基环戊-2-烯酮衍生物。
