Ho K L
Department of Pathology, Henry Ford Hospital, Detroit, MI 48202.
Arch Pathol Lab Med. 1989 Aug;113(8):874-9.
Malacoplakia was found in the brain biopsy specimen from the wall of a cystic lesion in a 4-month-old girl. Ultrastructural study of the Michaelis-Gutmann bodies revealed that the initial stage of calcification appeared to be the deposit of needle-shaped apatite crystals within intracytoplasmic membrane-bound vesicles of histiocytes. Accumulation of apatite crystals and coalescense of calcified vesicles resulted in the formation of large laminated calcospherules. Extracellular Michaelis-Gutmann bodies and apatite crystal-containing matrix vesicles were also noted. Calcified vesicles and the Michaelis-Gutmann bodies were not observed in the phagolysosomes. Bacteria and viral particles were not identified. These findings suggest that matrix and intracytoplasmic membrane-bound vesicles play an important role in the initial stage of the formation of Michaelis-Gutmann bodies and that a mechanism other than bacterial or viral infection may be involved in cerebral malacoplakia.
在一名4个月大女孩囊性病变壁的脑活检标本中发现了软斑病。对迈克尔is-古特曼小体的超微结构研究表明，钙化的初始阶段似乎是针状磷灰石晶体沉积在组织细胞的胞质内膜结合囊泡内。磷灰石晶体的积累和钙化囊泡的融合导致形成大的层状钙球。还注意到细胞外迈克尔is-古特曼小体和含磷灰石晶体的基质囊泡。在吞噬溶酶体中未观察到钙化囊泡和迈克尔is-古特曼小体。未鉴定出细菌和病毒颗粒。这些发现表明，基质和胞质内膜结合囊泡在迈克尔is-古特曼小体形成的初始阶段起重要作用，并且除细菌或病毒感染之外的机制可能参与脑软斑病。
