Soltesz Kristian, Sturk Christopher, Paskevicius Audrius, Liao Qiuming, Qin Guangqi, Sjoberg Trygve, Steen Stig
IEEE Trans Biomed Eng. 2017 Jun;64(6):1310-1317. doi: 10.1109/TBME.2016.2602228. Epub 2016 Aug 25.
Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.
Dynamic modeling and system identification were based on in vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties and reliability of operation of the resulting control system were evaluated in vivo.
The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.
Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.
Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.
目的：本文旨在证明一种新型闭环控制疗法在预防心跳脑死亡猪模型高血压方面的可行性。
基于体内数据进行动态建模和系统识别。针对识别出的模型获得了鲁棒控制器设计。在体内评估了所得控制系统的干扰衰减特性和运行可靠性。
控制系统对外部干扰的响应既可预测又一致。在完全自主运行的24小时内，有可能防止平均动脉压降至用户指定的参考值以下。
识别出的模型中的参数变异性证实了所提议疗法闭环控制给药的益处。评估的鲁棒控制器能够减轻过程不确定性和外部干扰。
预防高血压对于心跳脑死亡器官捐献者的护理至关重要。其自动化可能会增加适合从该患者群体进行移植的器官比例。
