Ogueh O, Johnson M R, Benjamin A
Department of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital , 687 Pine Avenue West, Montreal , Canada H3A 1A1.
Academic Obstetrics and Gynaecology, Imperial College School of Medicine, Chelsea and Westminster Hospital , 369 Fulham Road, London SW10 9NH , UK.
Obstet Med. 2009 Dec;2(4):157-60. doi: 10.1258/om.2009.090047. Epub 2009 Nov 30.
The aim of this study was to determine the effect of heparin thromboprophylaxis during pregnancy on maternal biochemical markers of bone metabolism. This was a prospective longitudinal study of carboxy terminal pro-peptide of type I collagen (PICP) and cross-linked carboxyterminal telopeptide of type I collagen (ICTP) levels in 15 women, who had heparin thromboprophylaxis during pregnancy compared with those of 18 normal pregnant controls. During pregnancy, the rate of change of PICP and ICTP in women who had heparin thromboprophylaxis was similar to those of women who did not (P = 0.184 for PICP, and P = 0.129 for ICTP), and PICP and ICTP levels at individual time points were similar in both groups. Therefore, heparin thromboprophylaxis during pregnancy does not affect maternal biochemical markers of bone metabolism.
本研究的目的是确定孕期肝素预防血栓形成对母体骨代谢生化标志物的影响。这是一项前瞻性纵向研究，对15名孕期接受肝素预防血栓形成的女性和18名正常怀孕对照组女性的I型胶原羧基末端前肽（PICP）和I型胶原交联羧基末端肽（ICTP）水平进行了研究。孕期，接受肝素预防血栓形成的女性中PICP和ICTP的变化率与未接受者相似（PICP的P = 0.184，ICTP的P = 0.129），且两组在各个时间点的PICP和ICTP水平相似。因此，孕期肝素预防血栓形成不影响母体骨代谢生化标志物。
