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选择性5-羟色胺-去甲肾上腺素再摄取抑制剂诱发的应激性心肌病

Selective Serotonin-norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy.

作者信息

Vasudev Rahul, Rampal Upamanyu, Patel Hiten, Patel Kunal, Bikkina Mahesh, Shamoon Fayez

机构信息

Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.

Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA.

出版信息

N Am J Med Sci. 2016 Jul;8(7):312-5. doi: 10.4103/1947-2714.187153.

DOI:10.4103/1947-2714.187153
PMID:27583240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4982361/
Abstract

CONTEXT

Takotsubo translates to "octopus pot" in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC.

CASE REPORT

We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far.

CONCLUSION

SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC.

摘要

背景

“Takotsubo”在日语中意为“章鱼壶”。Takotsubo心肌病（TTC）的特征是左心室短暂性局部收缩功能障碍。儿茶酚胺过量是研究最多且最受认可的解释TTC病理生理学的理论之一。

病例报告

我们报告了一例52岁西班牙裔女性因文拉法辛诱发TTC的病例，并回顾了迄今为止发表的所有与5-羟色胺-去甲肾上腺素再摄取抑制剂（SNRI）相关的TTC病例的文献。

结论

SNRI抑制儿茶酚胺再摄取进入突触前神经元，导致神经元突触中肾上腺素和5-羟色胺浓度净增加，并引起医源性儿茶酚胺过量，最终导致TTC。

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Selective Serotonin-norepinephrine Reuptake Inhibitors-induced Takotsubo Cardiomyopathy.选择性5-羟色胺-去甲肾上腺素再摄取抑制剂诱发的应激性心肌病
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本文引用的文献

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High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner: a new model of Takotsubo cardiomyopathy.高水平循环肾上腺素以β2-肾上腺素能受体/Gi 依赖性方式触发心尖心脏抑制：Takotsubo 心肌病的新模式。
Circulation. 2012 Aug 7;126(6):697-706. doi: 10.1161/CIRCULATIONAHA.112.111591. Epub 2012 Jun 25.
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Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors.与 5-羟色胺/去甲肾上腺素再摄取抑制剂摄入相关的心脏章鱼壶心肌病。
Heart Lung Circ. 2012 Apr;21(4):203-5. doi: 10.1016/j.hlc.2011.12.004. Epub 2012 Jan 27.
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抗抑郁药和抗肥胖药诱发的血清素综合征并发多器官损伤：一例报告。
Medicine (Baltimore). 2025 Apr 11;104(15):e41626. doi: 10.1097/MD.0000000000041626.
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