Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University , Richmond, VA , USA.
Department of Internal Medicine, Division of Pulmonary Disease and Critical Care Medicine, School of Medicine, Virginia Commonwealth University , Richmond, VA , USA.
Front Pediatr. 2016 Aug 17;4:80. doi: 10.3389/fped.2016.00080. eCollection 2016.
The field of stem cell biology, cell therapy, and regenerative medicine has expanded almost exponentially, in the last decade. Clinical trials are evaluating the potential therapeutic use of stem cells in many adult and pediatric lung diseases with vascular component, such as bronchopulmonary dysplasia (BPD), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), or pulmonary arterial hypertension (PAH). Extensive research activity is exploring the lung resident and circulating progenitor cells and their contribution to vascular complications of chronic lung diseases, and researchers hope to use resident or circulating stem/progenitor cells to treat chronic lung diseases and their vascular complications. It is becoming more and more clear that progress in mechanobiology will help to understand the various influences of physical forces and extracellular matrix composition on the phenotype and features of the progenitor cells and stem cells. The current review provides an overview of current concepts in the field.
在过去的十年中，干细胞生物学、细胞治疗和再生医学领域几乎呈指数级扩张。临床试验正在评估干细胞在许多伴有血管成分的成人和儿科肺部疾病中的潜在治疗用途，如支气管肺发育不良 (BPD)、慢性阻塞性肺疾病 (COPD)、特发性肺纤维化 (IPF) 或肺动脉高压 (PAH)。大量研究活动正在探索肺固有和循环祖细胞及其对慢性肺部疾病血管并发症的贡献，研究人员希望使用固有或循环的干细胞/祖细胞来治疗慢性肺部疾病及其血管并发症。越来越明显的是，机械生物学的进展将有助于了解物理力和细胞外基质组成对祖细胞和干细胞表型和特征的各种影响。目前的综述概述了该领域的当前概念。
