Bardi G, Pandis N, Arsenis P, Stamatellou M, Dermitzaki K, Papanastasiou C, Tsakanikas S, Kallinikou-Maniatis A
Department of Cellular Physiology, Papanikolaou Research Center, Athens, Greece.
Cancer Genet Cytogenet. 1989 Jul 1;40(1):83-7. doi: 10.1016/0165-4608(89)90148-9.
We present a case of acute leukemia with morphologic, cytochemical, and immunophenotypic markers indicating that the population of blasts have characteristics of lymphoid and myelomonocytic origin. The cytogenetic study revealed the following mosaic abnormal karyotype: 46XX,dup(1)(q21----32)/46,XX,dup(11)(q13----25)/47,XX,trip(11) (q13----25),+der(17)t(17;?) (q24;?). The two clones involving #11 are obviously related. It is reasonable to assume that the third clone is an evolutionary result of the second one. Because no cytogenetic similarities were found among the first clone and the other two, we suggest that this mixed leukemia was of biclonal origin. To our knowledge, acute leukemia with mixed lineage characteristics and with the simultaneous presence of cytogenetically unrelated clones has not previously been reported.
我们报告一例急性白血病病例，其形态学、细胞化学和免疫表型标志物表明原始细胞群体具有淋巴样和髓单核细胞起源的特征。细胞遗传学研究显示以下嵌合异常核型：46XX，dup(1)(q21----32)/46,XX,dup(11)(q13----25)/47,XX,trip(11)(q13----25),+der(17)t(17;?)(q24;?)。涉及11号染色体的两个克隆明显相关。合理推测第三个克隆是第二个克隆的进化结果。由于在第一个克隆与其他两个克隆之间未发现细胞遗传学相似性，我们认为这种混合性白血病是双克隆起源。据我们所知，此前尚未报道过具有混合谱系特征且同时存在细胞遗传学上不相关克隆的急性白血病。
