Asou N, Sanada I, Tanaka K, Hidaka M, Suzushima H, Matsuzaki H, Kawano F, Takatsuki K
Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
Cancer Genet Cytogenet. 1992 Jul 15;61(2):197-200. doi: 10.1016/0165-4608(92)90086-n.
We report a case of chronic myeloid leukemia (CML) in myelomonocytic transformation associated with bone marrow (BM) eosinophilia. At diagnosis, all BM cells showed a Ph chromosome. At the time of blastic phase, more than 50% of Ph+ cells had a pericentric inversion of chromosome 16, inv(16)(p13q22). This case confirms that blastic transformation of CML can involve any committed progenitor, and myelomonocytic leukemia with BM eosinophilia is specifically associated with rearrangement of chromosome 16 at band p13 and q22.
我们报告一例慢性髓性白血病（CML）发生髓单核细胞转化并伴有骨髓嗜酸性粒细胞增多。诊断时，所有骨髓细胞均显示费城染色体。在急变期，超过50%的Ph+细胞发生了16号染色体的臂间倒位，inv(16)(p13q22)。该病例证实CML的急变可累及任何定向祖细胞，且伴有骨髓嗜酸性粒细胞增多的髓单核细胞白血病与16号染色体p13和q22带的重排特异性相关。
