Mameniškienė Rūta, Rimšienė Justė, Puronaitė Roma
Clinic of Neurology and Neurosurgery, Faculty of Medicine, Vilnius University, Vilnius, Lithuania; Epilepsy Centre, Department of Neurology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Epilepsy Behav. 2016 Oct;63:89-97. doi: 10.1016/j.yebeh.2016.07.029. Epub 2016 Aug 30.
The aims of our study were to evaluate cognitive decline in people with temporal lobe epilepsy over a period of 13years and to determine what clinical and treatment characteristics may have been associated with these.
Thirty-three individuals with temporal lobe epilepsy underwent the same neuropsychological assessment of verbal and nonverbal memory, attention, and executive functions using the same cognitive test battery as one used 13years ago. Long-term verbal and nonverbal memory was tested four weeks later. Results were compared with those carried out 13years earlier.
There was no significant change in verbal and verbal-logical memory tests; however, nonverbal memory worsened significantly. Long-term verbal memory declined for 21.9% of participants, long-term verbal-logical memory for 34.4%, and long-term nonverbal memory for 56.3%. Worsening of working verbal and verbal-logical memory was associated with longer epilepsy duration and lower levels of patients' education; worsening of verbal delayed recall and long-term verbal-logical memory was associated with higher seizure frequency. Decline in long-term nonverbal memory had significant association with a longer duration of epilepsy. The worsening of reaction and attention inversely correlated with the symptoms of depression.
Over a 13-year period, cognitive functions did not change significantly. Good seizure control and reduced symptoms of depression in this sample of people with temporal lobe epilepsy were associated with better cognitive functioning. The predictors of change of cognitive functions could be complex and require further study.
我们研究的目的是评估颞叶癫痫患者在13年期间的认知衰退情况，并确定哪些临床和治疗特征可能与之相关。
33名颞叶癫痫患者使用与13年前相同的认知测试组合，接受了相同的关于言语和非言语记忆、注意力及执行功能的神经心理学评估。四周后对长期言语和非言语记忆进行测试。将结果与13年前的测试结果进行比较。
言语和言语逻辑记忆测试无显著变化；然而，非言语记忆显著恶化。21.9%的参与者长期言语记忆下降，34.4%的参与者长期言语逻辑记忆下降，56.3%的参与者长期非言语记忆下降。工作言语和言语逻辑记忆的恶化与癫痫病程较长及患者教育水平较低有关；言语延迟回忆和长期言语逻辑记忆的恶化与癫痫发作频率较高有关。长期非言语记忆的下降与癫痫病程较长有显著关联。反应和注意力的恶化与抑郁症状呈负相关。
在13年期间，认知功能没有显著变化。在这个颞叶癫痫患者样本中，良好的癫痫控制和抑郁症状的减轻与更好的认知功能相关。认知功能变化的预测因素可能很复杂，需要进一步研究。
