Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Students Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran.
Neurol Sci. 2019 Jun;40(6):1209-1216. doi: 10.1007/s10072-019-03818-2. Epub 2019 Mar 13.
Medial temporal lobe epilepsy (mTLE) has been associated with widespread white mater (WM) alternations in addition to mesial temporal sclerosis (MTS). Herein, we aimed to investigate the correlation between disease duration and WM structural abnormalities in mTLE using diffusion MRI (DMRI) connectometry approach.
DMRI connectometry was conducted on 24 patients with mTLE. A multiple regression model was used to investigate white matter tracts with microstructural correlates to disease duration, controlling for age and sex. DMRI data were processed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function (SDF). The SDF values were converted to quantitative anisotropy (QA) and used in further analyses.
Connectometry analysis identified impaired white matter QA of the following fibers to be correlated with disease duration: bilateral retrosplenial cingulum, bilateral fornix, right inferior longitudinal fasciculus (ILF), and genu of corpus callosum (CC) (FDR = 0.009).
Our results were obtained from DMRI connectometry, which indicates the connectivity and the level of diffusion in nerve fibers rather just the direction of diffusion. Compared to previous studies investigating the correlation between duration of epilepsy and white matter integrity in mTLE patients, we detected broader and somewhat different associations in midline structures and component of limbic system. However, further studies with larger sample sizes are required to elucidate previous and current results.
除了内侧颞叶硬化（MTS）之外，内侧颞叶癫痫（mTLE）还与广泛的白质（WM）改变有关。在此，我们旨在使用扩散 MRI（DMRI）连接测量法研究 mTLE 疾病持续时间与 WM 结构异常之间的相关性。
对 24 例 mTLE 患者进行 DMRI 连接测量。使用多元回归模型，在控制年龄和性别后，研究与疾病持续时间相关的白质束的微观结构相关性。使用 q-空间的弥散重建对 DMRI 数据进行 MNI 空间处理，以获得自旋分布函数（SDF）。将 SDF 值转换为定量各向异性（QA），并用于进一步分析。
连接测量分析确定与疾病持续时间相关的以下纤维的白质 QA 受损：双侧后扣带回、双侧穹窿、右侧下纵束（ILF）和胼胝体膝部（CC）（FDR=0.009）。
我们的结果来自于 DMRI 连接测量，它表示神经纤维的连通性和扩散水平，而不仅仅是扩散的方向。与之前研究 mTLE 患者癫痫持续时间与白质完整性之间的相关性相比，我们在中线结构和边缘系统的组成部分中检测到了更广泛和有些不同的关联。然而，需要更大样本量的进一步研究来阐明以前和当前的结果。
