Holaday J W, Wei E, Loh H H, Li C H
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2923-7. doi: 10.1073/pnas.75.6.2923.
Administration of the opiate antagonist naloxone to rats after acute or chronic heat exposure precipitates an increase in colonic temperature, an increase in escape attempts, and a decrease in body weight. These changes are accompanied by signs associated with hyperthermia such as salivation, diarrhea, and an abnormal extended posture. Although brain endorphin involvement is possible, hypophysectomy diminishes the intensity and magnitude of these naloxone effects, indicating that the naloxone effect in intact animals may be due to a functional antagonism of pituitary endorphins. These observations suggest that endorphins attenuate physiological responses to thermal and noxious stimuli triggered in common neuroanatomical pathways by heat.
在急性或慢性热暴露后给大鼠注射阿片类拮抗剂纳洛酮，会导致结肠温度升高、逃跑尝试增加以及体重下降。这些变化伴随着与体温过高相关的症状，如流涎、腹泻和异常伸展姿势。虽然大脑内啡肽可能参与其中，但垂体切除会减弱这些纳洛酮效应的强度和程度，这表明在完整动物中纳洛酮的作用可能是由于对垂体内啡肽的功能性拮抗。这些观察结果表明，内啡肽会减弱由热在共同神经解剖途径中引发的对热和有害刺激的生理反应。
