Does generalized hypo-oxygenation (hypoxia) allow endotoxin into the brain through the blood brain barrier, thus increasing the risk for Parkinson disease?
作者信息
Lange J H, Niehaus Ines, Cegolon Luca
机构信息
JH Lange, Envirosafe Training and Consultants, Pittsburgh, PA, USA,
出版信息
Croat Med J. 2016 Aug 31;57(4):406-7. doi: 10.3325/cmj.2016.57.406.
Abstract
摘要
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Does generalized hypo-oxygenation (hypoxia) allow endotoxin into the brain through the blood brain barrier, thus increasing the risk for Parkinson disease?全身性低氧（缺氧）是否会使内毒素通过血脑屏障进入大脑，从而增加患帕金森病的风险？
Croat Med J. 2016 Aug 31;57(4):406-7. doi: 10.3325/cmj.2016.57.406.
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本文引用的文献
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Hyperbaric oxygen preconditioning ameliorates blood-brain barrier damage induced by hypoxia through modulation of tight junction proteins in an in vitro model.在体外模型中，高压氧预处理通过调节紧密连接蛋白改善缺氧诱导的血脑屏障损伤。
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Somatostatin prevents lipopolysaccharide-induced neurodegeneration in the rat substantia nigra by inhibiting the activation of microglia.生长抑素通过抑制小胶质细胞的激活来预防脂多糖诱导的大鼠黑质神经变性。
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Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease.早期帕金森病患者的肠道通透性增加与乙状结肠黏膜α-突触核蛋白染色和内毒素暴露标志物相关。
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