Lack of splice factor and cohesin complex mutations in pediatric myelodysplastic syndrome.
作者信息
Obenauer Julia C, Kavelaars François G, Sanders Mathijs A, Hoogenboezem Remco M, de Vries Andrica C H, van Strien Paulina M H, de Haas Valerie, Locatelli Franco, Hasle Henrik, Valk Peter J M, Touw Ivo P, van den Heuvel-Eibrink Marry M
机构信息
Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Department of Pediatric Hemato-Oncology, Erasmus University Medical Center / Sophia Children's Hospital, Rotterdam, the Netherlands.
出版信息
Haematologica. 2016 Dec;101(12):e479-e481. doi: 10.3324/haematol.2016.151753. Epub 2016 Sep 1.
Abstract
摘要
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Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents.儿童和青少年 GATA2 相关性骨髓增生异常综合征的患病率、临床特征和预后。
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Clinical and biological implications of driver mutations in myelodysplastic syndromes.骨髓增生异常综合征中驱动突变的临床和生物学意义。
Blood. 2013 Nov 21;122(22):3616-27; quiz 3699. doi: 10.1182/blood-2013-08-518886. Epub 2013 Sep 12.
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Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.髓系肿瘤中黏连复合物多个成分的反复突变。
Nat Genet. 2013 Oct;45(10):1232-7. doi: 10.1038/ng.2731. Epub 2013 Aug 18.
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NRAS mutations with low allele burden have independent prognostic significance for patients with lower risk myelodysplastic syndromes.低等位基因负担的NRAS突变对低风险骨髓增生异常综合征患者具有独立的预后意义。
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Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia.严重先天性中性粒细胞减少症进展为急性髓系白血病时的连续突变获得。
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