珊瑚菌素A - C，源自珊瑚状猴头菇的具有神经生长和脑源性神经营养因子诱导活性的代谢产物。
Corallocins A-C, Nerve Growth and Brain-Derived Neurotrophic Factor Inducing Metabolites from the Mushroom Hericium coralloides.
作者信息
Wittstein Kathrin, Rascher Monique, Rupcic Zeljka, Löwen Eduard, Winter Barbara, Köster Reinhard W, Stadler Marc
机构信息
Department Microbial Drugs, Helmholtz Centre for Infection Research GmbH , Inhoffenstraße 7, 38124 Braunschweig, Germany.
German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig , 38124 Braunschweig, Germany.
出版信息
J Nat Prod. 2016 Sep 23;79(9):2264-9. doi: 10.1021/acs.jnatprod.6b00371. Epub 2016 Sep 2.
Three new natural products, corallocins A-C (1-3), along with two known compounds were isolated from the mushroom Hericium coralloides. Their benzofuranone and isoindolinone structures were elucidated by spectral methods. All corallocins induced nerve growth factor and/or brain-derived neurotrophic factor expression in human 1321N1 astrocytes. Furthermore, corallocin B showed antiproliferative activity against HUVEC and human cancer cell lines MCF-7 and KB-3-1.
从珊瑚状猴头菇中分离出三种新的天然产物——珊瑚菌素A-C（1-3）以及两种已知化合物。通过光谱方法阐明了它们的苯并呋喃酮和异吲哚啉酮结构。所有珊瑚菌素均可诱导人1321N1星形胶质细胞中神经生长因子和/或脑源性神经营养因子的表达。此外，珊瑚菌素B对人脐静脉内皮细胞（HUVEC）以及人癌细胞系MCF-7和KB-3-1具有抗增殖活性。
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