云南桑中具有抑制酪氨酸酶活性的苯并呋喃、类黄酮成分。

2-Arylbenzofuran, flavonoid, and tyrosinase inhibitory constituents of Morus yunnanensis.

机构信息

Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.

出版信息

J Nat Prod. 2012 Jan 27;75(1):82-7. doi: 10.1021/np2007318. Epub 2011 Dec 13.

DOI:10.1021/np2007318

PMID:22165973

Abstract

Two novel 2-arylbenzofuran dimers, morusyunnansins A and B (1 and 2), two new biflavonoids, morusyunnansins C and D (3 and 4), two new flavans, morusyunnansins E and F (5 and 6), and four known flavans (7-10) were isolated from the leaves of Morus yunnanensis. Compounds 5-8 showed potent inhibitory effects on mushroom tyrosinase with IC(50) values ranging from 0.12 ± 0.02 to 1.43 ± 0.43 μM.

摘要

从云南桑的叶子中分离得到两个新的 2-芳基苯并呋喃二聚体（morusyunnansins A 和 B，1 和 2）、两个新的双黄酮（morusyunnansins C 和 D，3 和 4）、两个新的黄烷（morusyunnansins E 和 F，5 和 6）和四个已知的黄烷（7-10）。化合物 5-8 对蘑菇酪氨酸酶具有很强的抑制作用，IC₅₀值范围为 0.12±0.02 至 1.43±0.43 μM。