Li Yan, Yu Qing, Zhang Zhengguo, Wang Jian, Li Simin, Zhang Jiangyuan, Liu Guangwei
Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing, China.
Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Oncotarget. 2016 Oct 25;7(43):71001-71012. doi: 10.18632/oncotarget.11681.
Naïve CD4+T cells differentiate into various T cell subsets depending on the specific cytokine environment. TH9 cells are less well-characterized than other T cell subsets, and factors that control their development and function have only recently been identified. It is now clear that TH9 cells play critical roles in immune-mediated diseases, including allergic airway, autoimmune and inflammatory bowel diseases, and cancer. Thus, the promotion or suppression of TH9 cell differentiation, transcriptional control and function may provide novel treatments for clinical inflammation, autoimmune diseases and tumors.
初始CD4+T细胞根据特定的细胞因子环境分化为各种T细胞亚群。与其他T细胞亚群相比，TH9细胞的特征尚不明确，控制其发育和功能的因素直到最近才被发现。现在已经清楚，TH9细胞在免疫介导的疾病中起关键作用，包括过敏性气道疾病、自身免疫性疾病、炎症性肠病和癌症。因此，促进或抑制TH9细胞分化、转录调控及其功能可能为临床炎症、自身免疫性疾病和肿瘤提供新的治疗方法。
