Berstein L M, Poroshina T E, Kovalenko I M, Vasilyev D A
N. N. Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Bull Exp Biol Med. 2016 Aug;161(4):547-9. doi: 10.1007/s10517-016-3457-4. Epub 2016 Sep 3.
Blood levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured by enzyme immunoassay after overnight fasting in untreated breast cancer and endometrial cancer patients (N=170) of mainly postmenopausal age with and without type 2 diabetes mellitus. The concentrations of 8-OHdG in patients with breast cancer were higher than in patients with endometrial cancer and in patients with breast cancer and diabetes in comparison with patients with breast cancer without diabetes. No correlations of blood 8-OHdG levels with glycemia, age, and clinical stage of disease were detected. In cancer patients with diabetes, the concentration of 8-OHdG increases proportionally to the increase in body mass index, though this does not lead to disappearance of the above differences between patients with breast cancer and endometrial cancer by the level of 8-OHdG. The causes of the trend to a less favorable course of tumor process in patients with breast cancer and diabetes in comparison with endometrial cancer and diabetes deserve further studies.
通过酶免疫测定法，在主要为绝经后年龄、患有和未患有2型糖尿病的未经治疗的乳腺癌和子宫内膜癌患者（N = 170）过夜禁食后，测量其血液中8-羟基-2'-脱氧鸟苷（8-OHdG）的水平。与无糖尿病的乳腺癌患者相比，乳腺癌患者的8-OHdG浓度高于子宫内膜癌患者以及患有乳腺癌和糖尿病的患者。未检测到血液8-OHdG水平与血糖、年龄和疾病临床分期之间的相关性。在患有糖尿病的癌症患者中，8-OHdG的浓度与体重指数的增加成比例增加，尽管这并未导致乳腺癌患者和子宫内膜癌患者之间上述8-OHdG水平差异的消失。与子宫内膜癌和糖尿病患者相比，乳腺癌和糖尿病患者肿瘤进程趋势较差的原因值得进一步研究。
