Laarman G J, Niemeyer M G, Bruschke A V, Verzijlbergen F J, Go T L, van der Wall E E, Ascoop C A
Department of Cardiology St. Antonius Hospital, Nieuwegein, The Netherlands.
Eur J Nucl Med. 1989;15(5):239-43. doi: 10.1007/BF00257540.
To establish test specific normal limits for quantitative analysis of uptake and washout of 201Tl after dipyridamole infusion combined with low level exercise, 20 healthy volunteers were studied with low likelihood of coronary artery disease (CAD) assessed by a stepwise probability analysis based on age, sex, symptoms, resting electrocardiogram, and exercise electrocardiography. Likelihood of CAD in these volunteers was calculated as less than or equal to 1%. After dipyridamole infusion combined with low level exercise, one volunteer complained of headache; no other side effects were observed. There were no chest pain complaints. Maximal hemodynamic changes were achieved during the 6th and 7th min of the test. No ST segment depression was recorded. Visual analysis of the 201Tl scintigrams was normal in all volunteers. Mean regional washout at 4 h was 44.37% +/- 2.11%. The regional washout in the 70 degrees LAO view (46.65% +/- 1.10%) was significantly higher than in the anterior and 30 degrees LAO views (43.44% +/- 1.50% and 43.02% +/- 1.45%, respectively). Profiles of uptake and washout of 201Tl were different after dipyridamole infusion combined with low level exercise as compared to maximal exercise. Thus, in quantitative analysis of 201Tl scintigraphy after dipyridamole infusion in conjunction with low level exercise as applied in the present study, it is mandatory to use normal limits of uptake and washout of 201Tl derived from healthy volunteers who underwent the same combined protocol.
为了建立双嘧达莫输注联合低水平运动后201Tl摄取和洗脱定量分析的特定检测正常范围，对20名健康志愿者进行了研究，这些志愿者患冠状动脉疾病（CAD）的可能性较低，通过基于年龄、性别、症状、静息心电图和运动心电图的逐步概率分析进行评估。这些志愿者患CAD的可能性经计算小于或等于1%。双嘧达莫输注联合低水平运动后，一名志愿者抱怨头痛；未观察到其他副作用。无胸痛主诉。在测试的第6和第7分钟达到最大血流动力学变化。未记录到ST段压低。所有志愿者的201Tl闪烁图视觉分析均正常。4小时时的平均局部洗脱率为44.37%±2.11%。70度左前斜位（LAO）视图的局部洗脱率（46.65%±1.10%）显著高于前位和30度LAO视图（分别为43.44%±1.50%和43.02%±1.45%）。与最大运动相比，双嘧达莫输注联合低水平运动后201Tl的摄取和洗脱曲线不同。因此，在本研究应用的双嘧达莫输注联合低水平运动后201Tl闪烁显像的定量分析中，必须使用接受相同联合方案的健康志愿者得出的201Tl摄取和洗脱正常范围。
