Kobayashi Y, Kobayashi N, Minaga T, Ogawa M, Shigematsu A
Bayer Yakuhin, Ltd., Osaka, Japan.
Eur J Drug Metab Pharmacokinet. 1989 Jan-Mar;14(1):43-56. doi: 10.1007/BF03190841.
The metabolism and kinetics of unmodified human IgG (125I-C-425) was studied in rats and rabbits after intravenous injection with regard to changes as a function of time of radioactivity in the blood and other tissues, excretion into the bile and placental permeability. A microautoradiographic study on the cellular interaction between 125I-C-425 and rat tissues was also performed using 125I-Polyglobin as the control drug. Results showed plasma radioactivity to be the highest followed by blood, lung, heart, kidney, bone marrow etc. in decreasing order. Tissues considered to contain larger amounts of blood, gave higher radioactivity values with some exceptions, such as the thyroid and skin. Biliary excretion within 72 hours was 7.57% for 125I-C-425 and 10.74% for 125I-Polyglobin. In pregnant rats, relatively high radioactivity was counted in the ovarium, uterus and placenta, and radioactivity in the fetus and amniotic fluid approached that of uterus and placenta up to 72 hours, indicating that placental permeability was gradual. Microautoradiographic findings revealed no cellular interaction such as aggregate formation, between human IgG and rat tissues. Further study is needed to elucidate immunological interaction under pathological conditions.
在大鼠和兔子静脉注射未修饰的人IgG（125I-C-425）后，研究了其代谢和动力学，涉及血液和其他组织中放射性随时间的变化、胆汁排泄及胎盘通透性。还使用125I-多球蛋白作为对照药物，对125I-C-425与大鼠组织之间的细胞相互作用进行了显微放射自显影研究。结果显示，血浆放射性最高，其次是血液、肺、心脏、肾脏、骨髓等，放射性依次降低。被认为含有较多血液的组织，放射性值较高，但甲状腺和皮肤等除外。125I-C-425在72小时内的胆汁排泄率为7.57%，125I-多球蛋白为10.74%。在怀孕大鼠中，卵巢、子宫和胎盘中的放射性相对较高，胎儿和羊水中的放射性在72小时内接近子宫和胎盘，表明胎盘通透性是逐渐变化的。显微放射自显影结果显示，人IgG与大鼠组织之间不存在细胞相互作用，如聚集形成。需要进一步研究以阐明病理条件下的免疫相互作用。
