Schreiber H, Stolz G, Rothmeier J, Kornhuber H H, Born J
Abteilung Neurologie, Universität Ulm, Federal Republic of Germany.
Eur Arch Psychiatry Neurol Sci. 1989;238(4):185-8. doi: 10.1007/BF00381462.
In previous studies investigating long latency components of the event-related potential (ERP), schizophrenic patients generally showed reduced P3 amplitudes and in some studies prolonged N2 or P3 latencies. As there is a higher risk of offspring of schizophrenics than of mentally healthy parents developing this disease, the present study was intended to clarify whether ERP components (in particular the N2 and P3) differ between these two groups of children. Twelve high-risk and 12 age-matched control children (aged 9-16 years) performed an auditory oddball task in order to assess late ERP components. This task required the subject to covertly count rare target tone pips (P = 0.2) irregularly interspersed among frequent standard tone pips (P = 0.8) in two series of 400 pips. ERPs were recorded from midline electrodes (Fz, Cz, Pz). The results indicated distinctly prolonged N2 and P3 latencies in ERPs to target stimuli in children of schizophrenic patients. These findings suggest a slowed target classification in these children.
在之前关于事件相关电位（ERP）长潜伏期成分的研究中，精神分裂症患者通常表现出P3波幅降低，并且在一些研究中N2或P3潜伏期延长。由于精神分裂症患者的后代患此病的风险高于精神健康父母的后代，本研究旨在阐明这两组儿童的ERP成分（特别是N2和P3）是否存在差异。12名高危儿童和12名年龄匹配的对照儿童（9至16岁）进行了听觉Oddball任务，以评估晚期ERP成分。该任务要求受试者暗中计数在两个包含400个音调的系列中不规则穿插在频繁出现的标准音调（P = 0.8）中的罕见目标音调（P = 0.2）。ERP从头皮中线电极（Fz、Cz、Pz）记录。结果表明，精神分裂症患者子女的ERP对目标刺激的N2和P3潜伏期明显延长。这些发现表明这些儿童的目标分类速度减慢。
