PC12 pheochromocytoma and sympathetic nervous system derived trophic factors augment growth of neuroblastoma.
作者信息
Chelmicka-Schorr E, Checinski M E, Arnason B G
机构信息
Department of Neurology, University of Chicago, IL 60637.
出版信息
Eur J Cancer Clin Oncol. 1989 Jul;25(7):1057-9. doi: 10.1016/0277-5379(89)90388-x.
PMID:2759161
Abstract
A trophic factor secreted by PC12 rat pheochromocytoma augments growth of C1300 neuroblastoma clonal lines S20, N18 and C46, but does not affect growth of the NIE 115 line. A trophic factor present in newborn sympathetic ganglia has the same biological effect on neuroblastoma cell lines. PC12 cells and sympathetic ganglia are both of neural crest origin; possibly both secrete the same trophic factor.
摘要
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