Sympathetic ganglia augment growth of neuroblastoma in vitro.
作者信息
Chelmicka-Schorr E, Yu R C, Sportiello M G, Arnason B G
出版信息
Eur J Cancer Clin Oncol. 1985 Aug;21(8):957-64. doi: 10.1016/0277-5379(85)90115-4.
PMID:4043178
Abstract
The sympathetic nervous system modulates the growth of C-1300 mouse neuroblastoma (C-1300 NB) in vivo. We now report that the presence of sympathetic cervical ganglia in cultures containing C-1300 NB or dispersed S-20 neuroblastoma (S-20 NB) cells augments growth of these tumors in vitro. Sympathetic ganglia-conditioned medium increases proliferation and survival of S-20 NB cells, indicating that nervous system-derived growth factors can exert an effect on neoplastic cells.
摘要
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