由两种不同的酶进行肾上腺外肾上腺素生成。
Extraadrenal adrenaline formation by two separate enzymes.
作者信息
Ziegler M G, Kennedy B, Elayan H
机构信息
Department of Medicine, University of California, San Diego Medical Center 92103.
出版信息
Experientia. 1989 Aug 15;45(8):718-20. doi: 10.1007/BF01974566.
Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT). After surgical removal of the adrenal medullae tissue A levels ranged from 22% of control in the heart to 125% of control in the liver. Use of a novel assay to measure tissue A formation revealed that many tissues can synthesize A using PNMT and another enzyme that N-methylates both noradrenaline and dopamine. These enzymes are non-neuronal, inducible and synthesize a major fraction of tissue and urine A.
肾上腺素（A）由苯乙醇胺-N-甲基转移酶（PNMT）在肾上腺髓质中合成。手术切除肾上腺髓质组织后，心脏中的A水平为对照的22%，而肝脏中的A水平为对照的125%。使用一种新型测定法来测量组织A的形成，结果显示许多组织可利用PNMT和另一种能使去甲肾上腺素和多巴胺甲基化的酶来合成A。这些酶是非神经元性的、可诱导的，并且合成了组织和尿液中大部分的A。
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