孕期家兔肾上腺中苯乙醇胺 -N-甲基转移酶和儿茶酚 -O-甲基转移酶活性降低。
Decreased phenylethanolamine-N-methyltransferase and catechol-O-methyltransferase activity in rabbit adrenal glands during pregnancy.
作者信息
Parvez H, Parvez S, Raza-Bukhari A
出版信息
Br J Pharmacol. 1976 Jul;57(3):413-6. doi: 10.1111/j.1476-5381.1976.tb07682.x.
Abstract
1 Phenylethanolamine-N-methyltransferase (PNMT) activity in adrenal gland was lower than the control values at day 24 of rabbit pregnancy and fell throughout the gestational period. 2 Catechol-O-methyltransferase (COMT) activity during pregnancy and parturition followed a similar pattern to PNMT. 3 Adrenaline content of the adrenal gland declined significantly during the last few days of pregnancy but at parturition showed a tendency to return towards normal. 4 The biochemical mechanisms which result in a decline in PNMT and COMT activities and adrenaline concentration appear to be the consequence of modifications in endocrine gland secretion during pregnancy.
摘要
- 兔妊娠第24天时，肾上腺中苯乙醇胺 - N - 甲基转移酶（PNMT）活性低于对照值，且在整个妊娠期持续下降。2. 妊娠和分娩期间儿茶酚 - O - 甲基转移酶（COMT）活性与PNMT呈现相似模式。3. 肾上腺中的肾上腺素含量在妊娠最后几天显著下降，但在分娩时呈现恢复正常的趋势。4. 导致PNMT和COMT活性以及肾上腺素浓度下降的生化机制似乎是妊娠期内分泌腺分泌改变的结果。
相似文献
1
Decreased phenylethanolamine-N-methyltransferase and catechol-O-methyltransferase activity in rabbit adrenal glands during pregnancy.孕期家兔肾上腺中苯乙醇胺 -N-甲基转移酶和儿茶酚 -O-甲基转移酶活性降低。
Br J Pharmacol. 1976 Jul;57(3):413-6. doi: 10.1111/j.1476-5381.1976.tb07682.x.
2
Fate of vasoactive biogenic amines and activity of enzyme phenylethanolamine-N-methyltransferase in rat adrenal gland during the course of pregnancy, parturition and postpartum.妊娠、分娩及产后大鼠肾上腺中血管活性生物胺的命运及苯乙醇胺 -N-甲基转移酶的活性
Gynecol Obstet Invest. 1979;10(5):254-64. doi: 10.1159/000299970.
3
Progesterone mediated increase in monoamine stores and the regulation of enzymes of biosynthesis and metabolism in the adrenal gland during late pregnancy in the rat.孕酮介导的大鼠妊娠后期肾上腺中单胺储存量的增加以及生物合成和代谢酶的调节。
Steroids. 1975 Nov;26(5):579-89. doi: 10.1016/0039-128x(75)90052-5.
4
Influence of progressive starvation upon brain and adrenal monoaminergic activity in developing rats of two different ages.渐进性饥饿对两种不同年龄发育中大鼠脑和肾上腺单胺能活性的影响。
Biol Neonate. 1979;35(5-6):224-34. doi: 10.1159/000241178.
5
Influence of repeated injections of estradiol during late pregnancy upon enzymes of monoamine metabolism and biosynthesis in the rat.妊娠后期重复注射雌二醇对大鼠单胺代谢及生物合成酶的影响。
Pharmacol Res Commun. 1976 Jun;8(3):283-94. doi: 10.1016/0031-6989(76)90018-7.
6
Enzymes for epinephrine synthesis and metabolism in the myometrium, endometrium, red blood cells, and plasma of pregnant human subjects.妊娠女性受试者子宫肌层、子宫内膜、红细胞及血浆中肾上腺素合成与代谢相关的酶。
Am J Obstet Gynecol. 1981 Dec 15;141(8):1009-18. doi: 10.1016/s0002-9378(16)32692-8.
7
Catecholamine metabolism in pargyline treated rats exposed to stress.接受帕吉林治疗的应激大鼠体内的儿茶酚胺代谢
Endocrinol Exp. 1980;14(2):147-50.
8
Hormone mediated changes in monoamine stores and regulation of enzymes of biosynthesis and metabolism in the rat adrenal gland. Influence of progesterone, estradiol, ACTH and testosterone administration.激素介导的大鼠肾上腺中单胺储备的变化以及生物合成和代谢酶的调节。孕酮、雌二醇、促肾上腺皮质激素和睾酮给药的影响。
Steroids. 1981 Jul;38(1):1-10. doi: 10.1016/0039-128x(81)90016-7.
9
Ontogeny of epinephrine metabolic pathways in the rat: role of glucocorticoids.大鼠肾上腺素代谢途径的个体发生：糖皮质激素的作用。
Int J Dev Neurosci. 2000 Feb;18(1):53-9. doi: 10.1016/s0736-5748(99)00106-9.
10
Alterations in activity of enzyme catechol-O-methyltransferase in central and peripheral regions of the rat and rabbit during pregnancy, parturition, and the postpartum period.大鼠和家兔在怀孕、分娩及产后期间中枢和外周区域儿茶酚-O-甲基转移酶活性的变化。
Am J Obstet Gynecol. 1979 Apr 15;133(8):880-5. doi: 10.1016/0002-9378(79)90305-3.
引用本文的文献
1
Regulation of catechol-O-methyltransferase expression in human myometrial cells.人子宫肌层细胞中儿茶酚-O-甲基转移酶表达的调控
Obstet Gynecol. 2006 Dec;108(6):1439-47. doi: 10.1097/01.AOG.0000243775.73788.11.
2
Effects of thyroidectomy and L-thyroxine on adrenaline and noradrenaline concentrations in the adrenal glands and plasma of rats during the pro-oestrous phase of the oestrous cycle and pregnancy.甲状腺切除术和L-甲状腺素对大鼠发情周期动情前期和妊娠期肾上腺及血浆中肾上腺素和去甲肾上腺素浓度的影响。
Br J Pharmacol. 1977 Feb;59(2):275-81. doi: 10.1111/j.1476-5381.1977.tb07490.x.
本文引用的文献
1
THE DISPOSITION OF CATECHOLAMINES IN THE RAT UTERUS AND THE EFFECT OF DRUGS AND HORMONES.儿茶酚胺在大鼠子宫中的分布以及药物和激素的影响。
J Pharmacol Exp Ther. 1964 May;144:150-5.
2
FLOW OF UTERINE BLOOD, AND THE OESTROUS CYCLE.子宫血流与发情周期
Nature. 1963 Jul 27;199:386-7. doi: 10.1038/199386a0.
3
Improved technique for the fluorimetric estimation of catecholamines.儿茶酚胺荧光测定的改进技术。
Acta Physiol Scand. 1961 Apr;51:348-55. doi: 10.1111/j.1748-1716.1961.tb02128.x.
4
Adrenaline formation in noradrenaline-storing chromaffin cells in vitro induced by corticosterone.皮质酮诱导体外储存去甲肾上腺素的嗜铬细胞中肾上腺素的生成。
J Endocrinol. 1966 Nov;36(3):317-24. doi: 10.1677/joe.0.0360317.
5
Corticosterone and methylation of noradrenaline by extra-adrenal chromaffin tissue.皮质酮与肾上腺外嗜铬组织对去甲肾上腺素的甲基化作用。
J Endocrinol. 1968 Aug;41(4):487-90. doi: 10.1677/joe.0.0410487.
6
Progesterone and 20-alpha-hydroxypregn-4-en-3-one in plasma, ovaries and uteri during pregnancy in the rat.大鼠孕期血浆、卵巢及子宫中的孕酮和20-α-羟基孕-4-烯-3-酮
Endocrinology. 1970 Jul;87(1):43-8. doi: 10.1210/endo-87-1-43.
7
Urinary excretion of epinephrine and norepinephrine during pregnancy.孕期肾上腺素和去甲肾上腺素的尿排泄情况。
J Clin Endocrinol Metab. 1970 Mar;30(3):357-60. doi: 10.1210/jcem-30-3-357.
8
Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy.大鼠发情周期和孕期卵巢静脉血中雌酮和雌二醇水平。
Biol Reprod. 1971 Dec;5(3):297-307. doi: 10.1093/biolreprod/5.3.297.
9
The oestrous cycle and monoamine oxidase activity.发情周期与单胺氧化酶活性
Br J Pharmacol. 1973 Aug;48(4):600-8. doi: 10.1111/j.1476-5381.1973.tb08246.x.
10
Corticosteroid levels in the mother and fetus of the rabbit during gestation.妊娠期家兔母体和胎儿体内的皮质类固醇水平。
Endocrinology. 1973 Dec;93(6):1342-8. doi: 10.1210/endo-93-6-1342.
Zotero 插件