Wilson T G, Jenkins P, Hoschtitzky A, McCabe M
Central Manchester Foundation Trust, Oxford Rd, Manchester M13 9WL, UK.
Ecancermedicalscience. 2016 Aug 15;10:664. doi: 10.3332/ecancer.2016.664. eCollection 2016.
To date, there have been less than a 100 confirmed case reports of primary cardiac malignant fibrous histiocytomas, a rare form of sarcoma. In this report, we discuss the case of a 15-year-old girl who initially presented with a histiocytic cerebral sarcoma that was treated with aggressive resection and chemotherapy. Three years later, the same patient developed increasing shortness of breath and was found to have a high-grade pleomorphic undifferentiated cardiac sarcoma that likely represents the primary tumour from which the cerebral lesion metastasised. This represents an extremely unique case; in 2010, a research group in Germany claimed the very first description of a true cardiac sarcoma with brain metastasis [1]. However, even as far back as 1960, there were three case reports [2] and more extensive sarcoma studies recently have revealed further cases [3]. Nevertheless, there have probably been less than 10 cases in the literature up until this point.
迄今为止，原发性心脏恶性纤维组织细胞瘤（一种罕见的肉瘤形式）的确诊病例报告不足100例。在本报告中，我们讨论了一名15岁女孩的病例，她最初表现为组织细胞性脑肉瘤，接受了积极的手术切除和化疗。三年后，该患者出现呼吸急促加重，被发现患有高级别多形性未分化心脏肉瘤，这可能是脑病变转移而来的原发性肿瘤。这是一个极其独特的病例；2010年，德国的一个研究小组首次描述了一例伴有脑转移的真正心脏肉瘤[1]。然而，早在1960年就有三例病例报告[2]，最近更广泛的肉瘤研究又发现了更多病例[3]。尽管如此，截至目前，文献中可能还不到10例。
