Kelly Deirdre, Mc Erlean Sarah, Byrne Danielle, Mahon Peter Mac, Mc Caffrey John
Department of Oncology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
Department of Radiology, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.
Radiol Case Rep. 2016 May 25;11(3):222-6. doi: 10.1016/j.radcr.2016.04.009. eCollection 2016 Sep.
Giant cell tumor of bone (GCTB) is a rare condition with distinct radiological features that aid diagnosis. We present the case of an adult female patient, with locally invasive GCTB and review important radiological and management principles. Specific radiological features include locally aggressive, lytic radiolucent lesions, which can demonstrate cortical thinning and expansile remodeling of bone and typically involve the epiphysis and metaphysis. Management is primarily surgical, and denosumab has a role in the advanced setting.
骨巨细胞瘤(GCTB)是一种罕见疾病,具有有助于诊断的独特放射学特征。我们报告一例成年女性局部侵袭性GCTB病例,并回顾重要的放射学及治疗原则。特定的放射学特征包括局部侵袭性的溶骨性透光性病变,可表现为皮质变薄和骨的膨胀性重塑,通常累及骨骺和干骺端。治疗主要为手术治疗,地诺单抗在晚期病例中发挥作用。