• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

一名骨骼未成熟患者肱骨近端骨骺处的骨巨细胞瘤:病例报告

Giant cell tumor of bone at the proximal epiphysis of humerus in a skeletally immature patient: A case report.

作者信息

Ramírez-González Manuel A, Olivella Gerardo, Ramírez Norman, Soler-Salas Antonio, Astacio Eric, Bibiloni Juan, Foy-Parilla Christian

机构信息

Orthopaedic Surgery Department, University of Puerto Rico, Medical Sciences Campus, San Juan, 00936-5067, Puerto Rico.

Pediatric Orthopaedic Surgery Department, Mayagüez Medical Center, Mayagüez, Puerto Rico.

出版信息

Int J Surg Case Rep. 2020;77:560-564. doi: 10.1016/j.ijscr.2020.11.112. Epub 2020 Nov 23.

DOI:10.1016/j.ijscr.2020.11.112
PMID:33395845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7701897/
Abstract

INTRODUCTION

Giant cell tumor of bone (GCTB) in skeletally immature (SI) patients are rare benign lesions that have locally aggressive growth pattern and high risk of recurrence. The presence of GCTB at the proximal epiphysis of humerus in SI patients has never been described in literature.

PRESENTATION OF CASE

This report shows the case of a 10-year-old SI male who presented with a GCTB at the proximal epiphysis of humerus that was treated with curettage, cement and adjuvant therapy.

DISCUSSION

The presence of a lytic growing lesion at the proximal humerus in a SI patient should alert clinicians to consider GCTB in their differential diagnosis. The management of GCTB in SI patients is challenging for orthopaedic surgeons. Tumor resection with cementation and adjuvant therapy has been described as a method rationale to prevent the recurrence and preserve the joint function in SI patients with GCTB at the proximal epiphysis of humerus. Clinicians should continue to monitor these patients with radiographic imaging for possible recurrence, metastasis or growth plate injury.

CONCLUSION

Tumor resection with cementation and adjuvant therapy offers a treatment alternative to prevent the recurrence and preserve the joint function in SI patients with GCTB at the proximal epiphysis of humerus. The use of a prothesis in a SI patient should avoided if possible, to prevent implant-related complications and damage to the growth plate.

摘要

引言

骨骼未成熟(SI)患者的骨巨细胞瘤(GCTB)是罕见的良性病变,具有局部侵袭性生长模式和高复发风险。文献中从未描述过SI患者肱骨近端骨骺出现GCTB的情况。

病例介绍

本报告展示了一名10岁SI男性的病例,该患者肱骨近端骨骺出现GCTB,接受了刮除、骨水泥填充及辅助治疗。

讨论

SI患者肱骨近端出现溶骨性生长病变应提醒临床医生在鉴别诊断时考虑GCTB。对于骨科医生而言,SI患者GCTB的治疗具有挑战性。肿瘤切除联合骨水泥填充及辅助治疗已被描述为预防肱骨近端骨骺GCTB的SI患者复发并保留关节功能的一种合理方法。临床医生应继续通过影像学检查监测这些患者,以发现可能的复发、转移或生长板损伤。

结论

肿瘤切除联合骨水泥填充及辅助治疗为预防肱骨近端骨骺GCTB的SI患者复发并保留关节功能提供了一种治疗选择。对于SI患者,应尽可能避免使用假体,以防止植入相关并发症和生长板损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/bb5f4458b9e4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/f595a99edb2f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/2d3201620b4e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/973b682961aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/28212608915c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/bb5f4458b9e4/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/f595a99edb2f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/2d3201620b4e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/973b682961aa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/28212608915c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea4e/7701897/bb5f4458b9e4/gr5.jpg

相似文献

1
Giant cell tumor of bone at the proximal epiphysis of humerus in a skeletally immature patient: A case report.一名骨骼未成熟患者肱骨近端骨骺处的骨巨细胞瘤:病例报告
Int J Surg Case Rep. 2020;77:560-564. doi: 10.1016/j.ijscr.2020.11.112. Epub 2020 Nov 23.
2
Rapidly growing giant cell tumor of bone in a skeletally immature girl.一名骨骼未成熟女孩的快速生长型骨巨细胞瘤。
Skeletal Radiol. 2016 Apr;45(4):567-73. doi: 10.1007/s00256-015-2276-4. Epub 2015 Nov 20.
3
Unusual presentation in Haiti of a recurrent giant cell tumor of bone affecting the distal radius: A case report.海地一名复发性骨巨细胞瘤累及桡骨远端的罕见病例报告。
Int J Surg Case Rep. 2021 Mar;80:105686. doi: 10.1016/j.ijscr.2021.105686. Epub 2021 Feb 22.
4
Giant Cell Tumor of Bone in Skeletally Immature Patients - A Clinical Perspective.骨骼未成熟患者的骨巨细胞瘤——临床视角
J Orthop Case Rep. 2015 Oct-Dec;5(4):57-60. doi: 10.13107/jocr.2250-0685.347.
5
Giant cell tumour of humerus: an unexpected lesion in a skeletally immature patient with Hodgkin's disease.肱骨巨细胞瘤:一名患有霍奇金病的骨骼未成熟患者身上出现的意外病变。
J Coll Physicians Surg Pak. 2014 Mar;24 Suppl 1:S37-8.
6
An Unusual Presentation of Giant Cell Tumor of the Tibia in a Skeletally Immature Patient.一名骨骼未成熟患者胫骨巨细胞瘤的罕见表现。
J Orthop Case Rep. 2018 May-Jun;8(3):10-13. doi: 10.13107/jocr.2250-0685.1086.
7
Enchondromas and atypical cartilaginous tumors at the proximal humerus treated with intralesional resection and bone cement filling with or without osteosynthesis: retrospective analysis of 42 cases with 6 years mean follow-up.肱骨近端内生软骨瘤和非典型性软骨肿瘤采用病灶内切除和骨水泥填充联合或不联合内固定治疗:6 年平均随访的 42 例回顾性分析。
World J Surg Oncol. 2018 Jul 13;16(1):139. doi: 10.1186/s12957-018-1437-z.
8
Treatment for giant cell tumor of the spine metastasizing to the lung: A report of two cases and a literature review.脊柱巨细胞瘤肺转移的治疗:两例报告及文献复习
Oncol Lett. 2015 Mar;9(3):1321-1326. doi: 10.3892/ol.2014.2837. Epub 2014 Dec 30.
9
[Diagnosis and treatment of giant cell tumor of bone in skeletal immature patients].[骨骼未成熟患者骨巨细胞瘤的诊断与治疗]
Zhonghua Wai Ke Za Zhi. 2013 Sep;51(9):827-30.
10
Population-based study of giant cell tumor of bone in Sweden (1983-2011).基于人群的瑞典骨巨细胞瘤研究(1983-2011)。
Cancer Epidemiol. 2016 Jun;42:82-9. doi: 10.1016/j.canep.2016.03.014. Epub 2016 Apr 6.

引用本文的文献

1
A Rationale for the Activity of Bone Target Therapy and Tyrosine Kinase Inhibitor Combination in Giant Cell Tumor of Bone and Desmoplastic Fibroma: Translational Evidences.骨靶向治疗与酪氨酸激酶抑制剂联合应用于骨巨细胞瘤和促纤维组织增生性纤维瘤的作用原理:转化医学证据
Biomedicines. 2022 Feb 3;10(2):372. doi: 10.3390/biomedicines10020372.

本文引用的文献

1
En bloc giant cell tumor resection following direct hemiarthroplasty shoulder reconstruction-functional outcome: A case report.直接半关节置换肩关节重建术后整块切除骨巨细胞瘤——功能结果:病例报告
Int J Surg Case Rep. 2019;61:202-206. doi: 10.1016/j.ijscr.2019.07.052. Epub 2019 Jul 26.
2
The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2018 声明:更新共识手术病例报告(SCARE)指南。
Int J Surg. 2018 Dec;60:132-136. doi: 10.1016/j.ijsu.2018.10.028. Epub 2018 Oct 18.
3
Giant Cell Tumor of Bone in Skeletally Immature Patients - A Clinical Perspective.
骨骼未成熟患者的骨巨细胞瘤——临床视角
J Orthop Case Rep. 2015 Oct-Dec;5(4):57-60. doi: 10.13107/jocr.2250-0685.347.
4
Giant cell tumour of the femur in a 9-year-old girl, resulting in severe leg length discrepancy.一名9岁女孩患有股骨巨细胞瘤,导致双下肢长度严重不等。
BMJ Case Rep. 2016 Mar 21;2016:bcr2015214265. doi: 10.1136/bcr-2015-214265.
5
Rapidly growing giant cell tumor of bone in a skeletally immature girl.一名骨骼未成熟女孩的快速生长型骨巨细胞瘤。
Skeletal Radiol. 2016 Apr;45(4):567-73. doi: 10.1007/s00256-015-2276-4. Epub 2015 Nov 20.
6
Giant cell tumour of the distal humerus: a case report.肱骨远端骨巨细胞瘤:一例报告
J Orthop Surg (Hong Kong). 2014 Dec;22(3):427-9. doi: 10.1177/230949901402200332.
7
Treating giant cell tumours with curettage, electrocautery, burring, phenol irrigation, and cementation.采用刮除术、电灼术、磨钻、苯酚冲洗和骨水泥填充治疗骨巨细胞瘤。
J Orthop Surg (Hong Kong). 2013 Aug;21(2):209-12. doi: 10.1177/230949901302100219.
8
Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study.地舒单抗治疗成人和骨骼成熟青少年骨巨细胞瘤的安全性和有效性:一项开放标签、平行组、2 期研究的中期分析。
Lancet Oncol. 2013 Aug;14(9):901-8. doi: 10.1016/S1470-2045(13)70277-8. Epub 2013 Jul 16.
9
Multicentric giant cell tumor in adolescents: three case reports.青少年多中心性巨细胞瘤:三例报告
J Pediatr Orthop B. 2013 May;22(3):282-7. doi: 10.1097/BPB.0b013e32835470da.
10
Long bones giant cells tumors: treatment by curretage and cavity filling cementation.长骨巨细胞瘤:刮除与空腔填充骨水泥填充治疗。
Orthop Traumatol Surg Res. 2009 Oct;95(6):402-6. doi: 10.1016/j.otsr.2009.07.004. Epub 2009 Sep 19.