Seol Young-Jun, Seon Jong-Keun, Lee Seung-Hun, Jin Cheng, Prakash Jatin, Park Yong-Jin, Song Eun-Kyoo
Department of Orthopedic Surgery, Center for Joint Disease, Chonnam National University Bitgoeul Hospital, Gwangju, Korea.
Lady Hardingemedical College, Delhi University, New Delhi, India.
Knee Surg Relat Res. 2016 Sep;28(3):188-93. doi: 10.5792/ksrr.2016.28.3.188. Epub 2016 Aug 25.
Total knee arthroplasty (TKA) accompanies the risk of bleeding and need for transfusion. There are several methods to reduce postoperative blood loss and blood transfusion. One such method is using tranexamic acid during TKA. The purpose of this study was to confirm whether tranexamic acid reduces postoperative blood loss and blood transfusion after TKA.
A total of 100 TKA patients were included in the study. The tranexamic acid group consisted of 50 patients who received an intravenous injection of tranexamic acid. The control included 50 patients who received a placebo injection. The amounts of drainage, postoperative hemoglobin, and transfusion were compared between the groups.
The mean amount of drainage was lower in the tranexamic acid group (580.6±355.0 mL) than the control group (886.0±375.5 mL). There was a reduction in the transfusion rate in the tranexamic acid group (48%) compared with the control group (64%). The hemoglobin level was higher in the tranexamic acid group than in the control group at 24 hours postoperatively. The mean units of transfusion were smaller in the tranexamic acid group (0.76 units) than in the control group (1.28 units).
Our data suggest that intravenous injection of tranexamic acid decreases the total blood loss and transfusion after TKA.
全膝关节置换术（TKA）存在出血风险及输血需求。有多种方法可减少术后失血和输血。其中一种方法是在TKA手术中使用氨甲环酸。本研究的目的是证实氨甲环酸是否能减少TKA术后的失血和输血情况。
本研究共纳入100例TKA患者。氨甲环酸组由50例接受氨甲环酸静脉注射的患者组成。对照组包括50例接受安慰剂注射的患者。比较两组之间的引流量、术后血红蛋白水平及输血量。
氨甲环酸组的平均引流量（580.6±355.0 mL）低于对照组（886.0±375.5 mL）。与对照组（64%）相比，氨甲环酸组的输血率有所降低（48%）。术后24小时，氨甲环酸组的血红蛋白水平高于对照组。氨甲环酸组的平均输血量（0.76单位）少于对照组（1.28单位）。
我们的数据表明，静脉注射氨甲环酸可减少TKA术后的总失血量和输血量。
