Kim Dong Hwi, Lee Gwang Chul, Lee Sang Hong, Pak Chi-Hyoung, Park Sang Ha, Jung Sung
Department of Orthopaedic Surgery, Chosun University Hospital, Gwangju, Korea.
Knee Surg Relat Res. 2016 Sep;28(3):194-200. doi: 10.5792/ksrr.2016.28.3.194. Epub 2016 Aug 25.
There are many methods to reduce massive bleeding during total knee arthroplasty (TKA). In our study, tranexamic acid and neutral drainage were used to decrease total blood loss.
The study was performed on 97 TKA patients from March 2012 to January 2013. In the study group, tranexamic acid was administered and neutral drainage was applied. The study group had group I (unilateral, n=29) and group III (bilateral, n=17). The control group had group II (unilateral, n=35) and group IV (bilateral, n=16).
In group I, the drainage volume on the 1st and 2nd postoperative days and the total drainage decreased with statistical significance (p<0.05). Between group III and group IV, group III had less drainage volume. In group III, the drainage volume on the 1st postoperative day and total drainage volume decreased statistically significantly (p<0.05). Between groups I and II, total blood loss showed no statistically significant difference, whereas between groups III and IV, the value was significantly different.
Intravenous administration of tranexamic acid with neutral drainage for 3 postoperative hours is a recommendable method because it can be helpful in reducing total blood loss in bilateral TKA.
全膝关节置换术（TKA）中有多种方法可减少大出血。在我们的研究中，使用氨甲环酸和中性引流来减少总失血量。
该研究于2012年3月至2013年1月对97例TKA患者进行。研究组给予氨甲环酸并采用中性引流。研究组有I组（单侧，n = 29）和III组（双侧，n = 17）。对照组有II组（单侧，n = 35）和IV组（双侧，n = 16）。
在I组中，术后第1天和第2天的引流量及总引流量减少，具有统计学意义（p < 0.05）。在III组和IV组之间，III组的引流量较少。在III组中，术后第1天的引流量和总引流量在统计学上显著减少（p < 0.05）。在I组和II组之间，总失血量无统计学显著差异，而在III组和IV组之间，该值有显著差异。
术后3小时静脉注射氨甲环酸并采用中性引流是一种值得推荐的方法，因为它有助于减少双侧TKA的总失血量。
