Kaercher T, Möbius D
Fortschr Ophthalmol. 1989;86(3):245-8.
In vitro experiments with meibomian gland secretion from healthy subjects, patients with keratoconjunctivitis sicca and meibomianitis were performed. In addition, patients of different age groups of both sexes were also tested. The biophysical experiments included continuous measurement of surface pressure and surface potential under compression and decompression conditions. Surface pressure was determined by a Wilhelmy type film balance; surface potential was determined using the vibrating plate method. In the age group up to 60 years, the surface potential of females, males and patients with keratoconjunctivitis sicca showed a characteristic peak of 200 mV under compression, which was fully reversible under decompression. Females, males and patients with keratoconjunctivitis sicca over 60 years of age showed changes in the surface potential under decompression which indicated that the secretion was unstable and inhomogeneons. Patients with meibomianitis presented characteristic changes of surface potential. Qualitative alteration of the secretion may be the corresponding interpretation. The above biophysical methods have been used for the first time under clinical aspects.
对健康受试者、干眼性角结膜炎患者和睑板腺炎患者的睑板腺分泌物进行了体外实验。此外，还对不同年龄组的男女患者进行了测试。生物物理实验包括在压缩和减压条件下连续测量表面压力和表面电位。表面压力由威尔海姆型薄膜天平测定；表面电位采用振动板法测定。在60岁及以下年龄组中，女性、男性和干眼性角结膜炎患者在压缩时表面电位呈现200 mV的特征峰，在减压时完全可逆。60岁以上的女性、男性和干眼性角结膜炎患者在减压时表面电位发生变化，表明分泌物不稳定且不均匀。睑板腺炎患者呈现出表面电位的特征性变化。分泌物的定性改变可能是相应的解释。上述生物物理方法首次应用于临床方面。
