Ekhtiyari Elham, Barzegar Mohammad, Mehdizadeh Amir, Shaaker Maghsood, Ghodoosifar Sepideh, Abhari Alireza, Darabi Masoud
Pediatric Health Research Center, Tabriz University of Medical Sciences, P.O. Box: 51367-35886, Tabriz, Iran.
Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Childs Nerv Syst. 2017 Jan;33(1):111-117. doi: 10.1007/s00381-016-3232-x. Epub 2016 Sep 5.
Meningitis is relatively common in infants and young children and can cause permanent brain damage. The aim of this study was to determine whether meningitis is associated with fatty acids in cerebrospinal fluid (CSF).
CSF samples from children between 3 months and 6 years of age admitted to the Tabriz public hospitals who met clinical criteria of meningitis were collected at enrollment. A total of 81 samples were analyzed for fatty acid profile by gas-liquid chromatography.
Children with a purulent meningitis demonstrated a higher percentage of oleic acid (p < 0.05, >10 %) and lower percentages of omega-3 polyunsaturated fatty acids (p < 0.001, <-40 %) than aseptic meningitis and nonmeningitis groups did. There was an inverse relationship between CSF long-chain omega-3 fatty acids and the total number of leukocytes and differential counts of neutrophils and lymphocytes in the purulent meningitis group. Moreover, significantly lower omega-3 fatty acids (p = 0.001, -37 %) and higher ratio of n-6/n-3 (p = 0.02, -29 %) were found in patients with purulent meningitis with sepsis than in those with meningitis and no sepsis.
This study provides evidence that purulent meningitis and its complication with sepsis are associated with important disturbances in CSF fatty acids, mainly deficiency in long-chain omega-3 polyunsaturated fatty acids.
脑膜炎在婴幼儿中相对常见，可导致永久性脑损伤。本研究旨在确定脑膜炎是否与脑脊液（CSF）中的脂肪酸有关。
收集大不里士公立医院收治的3个月至6岁符合脑膜炎临床标准儿童的脑脊液样本。共81份样本通过气液色谱法分析脂肪酸谱。
与无菌性脑膜炎和非脑膜炎组相比，化脓性脑膜炎患儿的油酸百分比更高（p < 0.05，>10%），ω-3多不饱和脂肪酸百分比更低（p < 0.001，<-40%）。在化脓性脑膜炎组中，脑脊液长链ω-3脂肪酸与白细胞总数以及中性粒细胞和淋巴细胞分类计数之间呈负相关。此外，与无败血症的脑膜炎患者相比，患有败血症的化脓性脑膜炎患者的ω-3脂肪酸显著降低（p = 0.001，-37%），n-6/n-3比值显著升高（p = 0.02，-29%）。
本研究提供的证据表明，化脓性脑膜炎及其败血症并发症与脑脊液脂肪酸的重要紊乱有关，主要是长链ω-3多不饱和脂肪酸缺乏。
