芬兰人和瑞典拉普人中血浆α1B-糖蛋白的等位基因频率：一种新的α1B等位基因的证据。

Plasma alpha 1B-glycoprotein allele frequencies in Finns and Swedish Lapps: evidence for a new alpha 1B allele.

作者信息

Juneja R K, Beckman G, Lukka M, Gahne B, Ehnholm C

机构信息

Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.

出版信息

Hum Hered. 1989;39(1):32-6. doi: 10.1159/000153828.

DOI:10.1159/000153828

PMID:2759622

Abstract

A new allele (A1B5) of human plasma alpha 1B-glycoprotein (alpha 1B) was reported. alpha 1B phenotyping was done by two-dimensional agarose gel (pH 5.4)-horizontal polyacrylamide gel (pH 9.0) electrophoresis followed by protein staining. The alpha 1B phenotypes 1-1, 1-2, 1-5 and 2-2 were observed in Finns and phenotypes 1-1, 1-2, 1-5 and 2-5 in Swedish Lapps. The respective frequencies of A1B1, A1B2 and A1B5 were 0.9575, 0.0350, 0.0075 in Finns and 0.8922, 0.0653, 0.0425 in Swedish Lapps. The Swedish Lapps showed a higher degree of alpha 1B polymorphism (polymorphism information content = 0.19) than other Caucasian populations that have been studied.

摘要

据报道，人类血浆α1B - 糖蛋白（α1B）出现了一个新的等位基因（A1B5）。α1B表型分析通过二维琼脂糖凝胶（pH 5.4）-水平聚丙烯酰胺凝胶（pH 9.0）电泳，随后进行蛋白质染色来完成。在芬兰人群中观察到α1B表型1 - 1、1 - 2、1 - 5和2 - 2，在瑞典拉普人中观察到表型1 - 1、1 - 2、1 - 5和2 - 5。在芬兰人群中，A1B1、A1B2和A1B5的各自频率分别为0.9575、0.0350、0.0075；在瑞典拉普人群中分别为0.8922、0.0653、0.0425。与其他已研究的高加索人群相比，瑞典拉普人表现出更高程度的α1B多态性（多态性信息含量 = 0.19）。