Human malic enzyme-2 polymorphism in the GDR.

Leukocyte malic enzyme-2 (ME2) phenotypes were studied in 313 blood samples from unselected subjects and in 241 human brain tissue samples (postmortem examinations) from the northern part of the GDR. The ME2(2) frequency was 0.34 and the same in blood and brain samples. The gene frequencies were in agreement with those previously reported for European populations. A study of 71 mother-child pairs supported a genetic transmission by two alleles at an autosomal locus.