Danielsson Karin, Ebrahimi Majid, Nylander Elisabet, Wahlin Ylva Britt, Nylander Karin
Department of Odontology, Umeå University, SE-90185 Umeå, Sweden.
Acta Derm Venereol. 2017 Feb 8;97(2):214-218. doi: 10.2340/00015555-2533.
Lichen planus is a chronic recurrent inflammatory disease affecting both skin and mucosa, mainly in oral and/or genital regions. Keratinocytes go through a well-regulated process of proliferation and differentiation, alterations in which may result in defects in the protective epithelial barrier. Long-term barrier impairment might lead to chronic inflammation. In order to broaden our understanding of the differentiation process in mucosal lichen planus, we mapped the expression of 4 factors known to be involved in differentiation. Biopsies were collected from oral and genital lichen planus lesions and normal controls. Altered expression of all 4 factors in epithelium from lichen planus lesions was found, clearly indicating disturbed epithelial differentiation in lichen planus lesions.
扁平苔藓是一种慢性复发性炎症性疾病，累及皮肤和黏膜，主要发生在口腔和/或生殖器部位。角质形成细胞经历一个受严格调控的增殖和分化过程，其中的改变可能导致保护性上皮屏障出现缺陷。长期的屏障损害可能导致慢性炎症。为了拓宽我们对黏膜扁平苔藓分化过程的理解，我们绘制了已知参与分化的4种因子的表达图谱。从口腔和生殖器扁平苔藓病变组织以及正常对照中采集活检样本。结果发现扁平苔藓病变上皮中所有4种因子的表达均发生改变，这清楚地表明扁平苔藓病变中上皮分化受到干扰。
