Almeda-Valdes Paloma, Aguilar-Salinas Carlos A, Uribe Misael, Canizales-Quinteros Samuel, Méndez-Sánchez Nahum
Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico.
Eur J Clin Invest. 2016 Nov;46(11):940-946. doi: 10.1111/eci.12672. Epub 2016 Oct 1.
The prevalence of obesity has increased worldwide in parallel with associated metabolic disturbances such as diabetes and non-alcoholic fatty liver disease.
The objective of this article is to underscore discrepancies in the standard anthropometric cut-off values and the presence of metabolic disturbances including diabetes and non-alcoholic fatty liver disease caused by biological and ethnic variations.
We performed a literature review regarding the diagnosis and prevalence of obesity, diabetes, metabolic syndrome and non-alcoholic fatty liver disease and about the different available indicators to define obesity.
There is an ongoing epidemic of these chronic diseases, partially attributed to the increased prevalence of obesity. The available markers to indicate adiposity are imperfect, and the selection of accurate cut-off points is still not clear.
Methods to quantify adiposity that are useful in clinical practice should be developed to better classify individuals and to reflect metabolic risk more appropriately.
全球肥胖症患病率呈上升趋势，同时伴有糖尿病和非酒精性脂肪性肝病等相关代谢紊乱。
本文旨在强调标准人体测量学临界值的差异，以及由生物学和种族差异导致的包括糖尿病和非酒精性脂肪性肝病在内的代谢紊乱情况。
我们对肥胖症、糖尿病、代谢综合征和非酒精性脂肪性肝病的诊断及患病率，以及用于定义肥胖症的不同可用指标进行了文献综述。
这些慢性病呈流行态势，部分原因是肥胖症患病率上升。用于指示肥胖的现有标志物并不完美，准确临界值的选择仍不明确。
应开发在临床实践中有用的肥胖量化方法，以更好地对个体进行分类，并更恰当地反映代谢风险。
