基于适配体的人体生物标志物体液筛选
Aptamer-Based Screens of Human Body Fluids for Biomarkers.
作者信息
Albaba Dania, Soomro Sanam, Mohan Chandra
机构信息
Department of Biomedical Engineering, University of Houston, 3605 Cullen Blvd, Houston, TX 77204, USA.
出版信息
Microarrays (Basel). 2015 Sep 22;4(3):424-31. doi: 10.3390/microarrays4030424.
Abstract
In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered.
摘要
近年来，适体已在高通量多重实验中取代了抗体。始于2010年的基于适体的生物标志物筛选技术，能够在非常小的样本量中检测数千种蛋白质。借助这项新技术，研究人员希望通过筛查人体体液来找到针对多种疾病的临床适用生物标志物。在这项工作中，我们总共回顾了八项利用基于适体的人体体液生物标志物筛查的研究，并突出了发现的新型蛋白质生物标志物。
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